Ferroptosis is a programmed cell death mainly manifested as accumulation of ferrous ions and lipid peroxidation. well regulated by multiple signaling pathways, which SLC7A11/GPX4 axis the key pathway negatively regulating ferroptosis eliminating While disorder iron homeostasis catalyzes peroxidation supplying iron. Lipid metabolism participates in offering substrates. In addition, transsulfurat...

The endoplasmic reticulum (ER) is an important player in regulating protein synthesis and lipid metabolism. Perturbation of ER homeostasis, referred as "ER stress," has been linked to numerous pathological conditions, such as inflammation, cardiovascular diseases, and metabolic disorders. The liver plays a central role in regulating nutrient and lipid metabolism. Accumulating evidence implicate...

Apigenin, a natural flavonoid has been reported against variety of cancer types. However, it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells. There are few reports on the mechanism endometrial We found that iron accumulation, lipid peroxidation, GSH consumption, p62, HMOX1, ferritin were increased, while, SLC7A11 GPX4 decreased. Fer-1, an iron-death inhibitor...

T mobilization of fatty acid from triglycerides and cholesterol esters provides the primary source of energy in mammals. Hormone-sensitive lipase (HSL) is a multifunctional tissue lipase that plays a critical role in this process. The enzyme has broad specificity, catalyzing the hydrolysis of tri-, di-, and monoacylglycerols, as well as cholesterol esters. HSL has been studied most extensively ...