To investigate the effect of salinity stress on membrane stability index, membrane lipid peroxidation, catalase activity and protein content of Fenugreek (Trigonellafoenum) an experiment with five levels of short-term salinity stress (0, 50, 100, 150 and 200 mM) was carried out at the laboratory of agriculture faculty of Shahid Bahonar University of Kerman, Iran. The treatments were ar...

Macroion adsorption on a mixed, fluid, lipid membrane containing oppositely charged lipids induces local changes in lipid composition at the interaction zones, and gradients at their boundaries. Including these effects in the free energy of the macroion-dressed membrane we derive its spinodal equation, and show that nonideal lipid mixing can lead to (lipid-mediated) attraction between macroions...

Lipid transport between membranes within cells involves vesicle and protein carriers, but as agents of nonvesicular lipid transfer, the role of membrane contact sites has received increasing attention. As zones for lipid metabolism and exchange, various membrane contact sites mediate direct associations between different organelles. In particular, membrane contact sites linking the plasma membr...

Abstract The Tweety homologs (TTYHs) are members of a conserved family eukaryotic membrane proteins that abundant in the brain. three human paralogs were assigned to function as anion channels either activated by Ca 2+ or cell swelling. To uncover their unknown architecture and its relationship function, we have determined structures TTYH1–3 cryo-electron microscopy. All display equivalent feat...

Sec14, a yeast phosphatidylinositol/phosphatidylcholine transfer protein, functions at the trans-Golgi membranes. It lacks domains involved in protein-protein or protein-lipid interactions and consists solely of Sec14 domain; hence, mechanism underlying function proper sites remains unclear. In this study, we focused on lipid packing membranes evaluated its association with vitro activity. Phos...

The structural properties of the lipids forming biological membranes determine a very high level of lateral organization within membranes. Lipid-driven membrane organization allows the segregation of membrane-associated components into membrane lipid domains, now worldwide known as lipid rafts, acting as dynamic platforms for signal transduction, protein processing and membrane turnover. Many p...

Lipid composition affects the biophysical properties of membranes that provide a platform for receptor-mediated cellular signaling. To study the regulatory role of membrane lipid composition, we combined genetic perturbations of sphingolipid metabolism with the quantification of diverse steps in Toll-like receptor (TLR) signaling and mass spectrometry-based lipidomics. Membrane lipid compositio...