The combination of an antifungal agent and drug carrier with adjunctive antimicrobial properties represents novel strategy of complex therapy in pharmaceutical technology. The goal of this study was to investigate the unmodified and ion cross-linked chitosan's influence on anti-Candida activity of clotrimazole used as a model drug in hydrogels. It was particularly crucial to explore whether the...

The paper describes the synthesis of pH sensitive interpenetrating polymeric network (IPN) beads composed of chitosan, glycine, glutamic acid, cross linked with glutaraldehyde and their use for controlled drug release. The drug was loaded into beads by varying their composition such as, amount of crosslinker glutaraldehyde, ratio of chitosan, glycine and glutamic acid. The beads were characteri...

Chitosan is an amino polysaccharide with exciting scientific uses because of its distinct structure and several various functions. High biocompatibility, strong biodegradability, low toxicity are some the chitosan's most notable characteristics. holds great promise for biomedical including targeted delivery drugs. Therefore, this research suggests tripolyphosphate (TPP)-based ionically cross-li...

A selectively cross-linking method, which is based on the ‘‘di–diol” interaction between poly(vinyl alcohol) and borate and the strong electrostatic interaction between chitosan and tripolyphosphate, was developed. Chitosan/poly(vinyl alcohol) films cross-linked separately with borate, tripolyphosphate and borate/tripolyphosphate were then prepared in terms of this method. Water vapor permeatio...

alpha-1antitrypsin (a1at) deficiency, an inherited disorder, has been shown to be the cause of lung diseases such as emphysema and chronic obstructive pulmonary disease. one of the treatment strategies to provide appropriate and adequate concentrations of a1at in the lungsis the application of nanoparticles (nps) in pulmonary drug delivery. in the current study, biocompatible nanohydrogels were...

Liposomes are commonly used to deliver drugs and contrast agents to their target site in a controlled manner. One of the greatest obstacles in the performance of such delivery vehicles is their stability in the presence of serum. Here, we demonstrate a method to stabilize a class of liposomes that load gadolinium, a magnetic resonance (MR) contrast agent, as a model cargo on their surfaces. We ...

The crustacean shells-derived polysaccharide chitosan has received much attention for its anti-obesity potential. Dietary supplementation of chitosan has been linked with reductions in feed intake, suggesting a potential link between chitosan and appetite control. Hence the objective of this experiment was to investigate the appetite suppressing potential of prawn shell derived chitosan in a pi...

Peptide vaccines using specific antigens with poor immunogenicity like GnRH-I are unable to develop an effective adaptive immune response and require the presence of adjuvants, essential to lymphocytic activation. Three chitosan formulations were evaluated for their ability as adjuvant of a poor immunogenic peptide vaccine against GnRH-I. Male Sprague-Dawley rats were immunized subcutaneously w...

in order to achieve prolong corneal contact time of norfloxacin(nfx) for treatment of extra ocular diseases, a ph triggered nanoparticulate in situ gelling system was designed to explore dual advantage of nanoparticles and in situ gelling system, for its ocular delivery. nfx loaded nanocarriers were developed by ionotropic gelation technique using chitosan as a matrix forming polymer, cross-lin...