نتایج جستجو برای: lineage leukemia

تعداد نتایج: 317209  

2003
Ryuji Shimamura Jiro Kudo Hiroko Kondo Kazufumi Dohmen Hisashi Gondo Seiichi Okamura Hiromi Ishibashi Yoshiyuki Niho

Thymosin 8, (TB,) was originally isolated as a thymic hormone. Its functional properties remain obscure; however, the N-terminal peptidic sequence could have a regulatory function on hematopoietic stem cell proliferation. To investigate the mechanism of TB, expression, we studied TB, gene expression in various leukemic cells and in established cell lines. Among leukemic cell samples obtained fr...

Journal: :Leukemia research 2009
Seung Hwan Oh Tae Sung Park Hye Ran Kim Ja Young Lee Jae Hyun Kim Jeong Hwan Shin Jeong Nyeo Lee

Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid.

Journal: :The Journal of clinical investigation 2005
Leo Kager Meyling Cheok Wenjian Yang Gianluigi Zaza Qing Cheng John C Panetta Ching-Hon Pui James R Downing Mary V Relling William E Evans

The ability of leukemia cells to accumulate methotrexate polyglutamate (MTXPG) is an important determinant of the antileukemic effects of methotrexate (MTX). We measured in vivo MTXPG accumulation in leukemia cells from 101 children with acute lymphoblastic leukemia (ALL) and established that B-lineage ALL with either TEL-AML1 or E2A-PBX1 gene fusion, or T-lineage ALL, accumulates significantly...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2008

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

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