نتایج جستجو برای: limited cutaneous scleroderma
تعداد نتایج: 485654 فیلتر نتایج به سال:
INTRODUCTION Microsomal prostaglandin E2 synthase-1 (mPGES-1) is an inducible enzyme that acts downstream of cyclooxygenase (COX) to specifically catalyze the conversion of prostaglandin (PG) H2 to PGE2. mPGES-1 plays a key role in inflammation, pain and arthritis; however, the role of mPGES-1 in fibrogenesis is largely unknown. Herein, we examine the role of mPGES-1 in a mouse model of skin sc...
INTRODUCTION CREST (calcinosis, Raynaud phenomenon, oesophageal dysmotility, sclerodactyly, and telangiectasia) syndrome comprising calcinosis cutis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia and primary sclerosing cholangitis are both chronic fibrotic diseases but the association between them is extremely rare. While primary sclerosing cholangitis has been as...
S ystemic sclerosis (SSc) is a systemic autoimmune disease that is characterised by endothelial dysfunction resulting in a small-vessel vasculopathy, fibroblast dysfunction with resultant excessive collagen production and fibrosis, and immunological abnormalities. The classification of SSc is subdivided based on the extent of skin involvement into diffuse cutaneous sclerosis (dcSSc), limited cu...
Scleroderma-like cutaneous lesions have been found in many pathological conditions and they the clinical appearance of sclerotic or scleroatrophic lesions. Affected skin biopsies described histopathological changes similar to those scleroderma located strictly on systemic sclerosis. These can be inflammatory diseases with autoimmune substrate (generalized morphea, chronic graft versus host dise...
Scleroderma renal crisis (SRC) is an infrequent complication of a rare disease. To date, many aspects of the pathophysiology of SRC are still mysterious. Since SRC biopsies are not frequently encountered in practice, our understanding of the spectrum of histologic changes is derived from a combination of a limited personal experience and data obtained from several relatively small pathologic st...
Here, we describe an atypical case of systemic sclerosis in its diffuse cutaneous form with acute and rapid progression of the cutaneous condition, without any systemic manifestations and the infrequent formation of bullae, showing the importance of diagnosis and early treatment in such cases. This case also shows that special measures should be taken for bullous cutaneous lesions and ulceratio...
Introduction: Patients with systemic sclerosis have a high prevalence of myocardial fibrosis, which has a potential negative impact on cardiac function. Diastolic dysfunction is a frequent echocardiographic finding in patients with scleroderma. The aim of this study was to evaluate the possible influence of myocardial fibrosis on the diastolic function of the left ventricle in patients with sys...
Subcutaneous calcinosis consists of abnormal calcium deposition in soft tissues and is one of the complications of scleroderma, especially in limited systemic sclerosis. It is one of the criteria of CREST syndrome (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia). A 44-year-old woman with systemic scleroderma for 20 years was presented with pain ...
OBJECTIVE To determine the frequency of pericardial and pleural effusions in scleroderma. METHODS Using a case-control format, patients with scleroderma and no known cardiac disease were recruited. Echocardiograms and chest radiographs were performed. Age- and gender-matched controls had echocardiograms performed which were read by a cardiologist, blinded to the diagnosis. The medical records...
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