BACKGROUND Early glucosteroid treatment in preterm infants has a negative impact on physical growth and development. So far, data on dexamethasone effect on the GH/IGF axis and the clinical outcome are conflicting. OBJECTIVE Therefore, we studied the effect of dexamethasone treatment on parameters of somatic growth and on the secretion of insulin like growth factors (IGFs) and insulin like gr...

Data from experimental model systems and population studies have implicated type I insulin-like growth factor receptor (IGF1R) signaling in many different human cancers. Drugs to disrupt IGF1R function have been developed and are now entering clinical trial. This brief review will identify key areas to consider as these clinical trials move forward.

There are two types of insulin-like growth factor (IGF) receptors. The type I receptor generally binds IGF-I more tightly than IGF-II and also interacts weakly with insulin. The type II receptor prefers IGF-II over IGF-I and does not recognize insulin. The type I receptor is made up of an alpha binding subunit (Mr 130000) and a beta subunit (Mr 95 000) probably organized as a heterotetramer (Oi...

in this study, total factor productivity growth of iran’s pulses (including irrigated pea, dry pea, irrigated lentil, dry lentil, irrigated soybean, dry soybean and irrigated bean) during of farming years 1989-1990 though 2007-2008 had been analyzed, using nonparametric malmquist approach. so, amounts of inputs usages include seeds, fertilizers, dung, poison, herbicide, labor, water and acreage...