نتایج جستجو برای: leydig

تعداد نتایج: 3705  

Journal: :The Journal of endocrinology 2007
Uniza W Khan Umesh Rai

The present study in the wall lizard, Hemidactylus flaviviridis, was aimed to understand the role of histamine (HA) in the regulation of Leydig cell and testicular macrophage activities, for the first time, in ectothermic vertebrates. Although HA did not affect the testosterone production from unstimulated Leydig cells, it had dual concentration-related effects, stimulatory at a low concentrati...

Journal: :American journal of physiology. Endocrinology and metabolism 2007
Guey-Shyang Hwang Shyi-Wu Wang Wen-Min Tseng Ching-Han Yu Paulus S Wang

Hypoxia has been shown to stimulate the expression of vascular endothelial growth factor (VEGF), which is a major mediator for angiogenesis and vasculogenesis. During hypoxia, VEGF promotes angiogenesis in the testis. However, the effect of VEGF on the steroidogenesis of testosterone and the cell proliferation in Leydig cells is unclear. To assess the effects and the action mechanisms of hypoxi...

Journal: :Asian journal of andrology 2005
Paul F Moundipa Nathalie Sara E Beboy Fabien Zelefack Silvére Ngouela Etienne Tsamo Wolf-Bernhard Schill Thomas K Monsees

AIM To determine the androgenic effects of Basella alba and Hibiscus macranthus extracts in the rat and the bull, and to develop a novel in vitro test system using Leydig cells from bull testes. METHODS The effect of methanol extracts from both plants on testosterone production in isolated Leydig cells from the rat and the bull was analyzed using 125I-radioimmunoassay (125I-RIA). Rat Leydig c...

Journal: :Journal of lipid research 2000
E Reaven L Zhan A Nomoto S Leers-Sucheta S Azhar

This study investigates the relationship between the high density lipoprotein (HDL) receptor (scavenger receptors, SR-BI and SR-BII), selective lipoprotein-cholesteryl ester uptake, and testosterone production in Leydig cells of control, hypocholesterolemic and gonadotrophic hormone (hCG) treated rats. Leydig cells from mature control rats show poor efficiency in incorporation of labeled HDL-ch...

Journal: :Asian journal of andrology 2006
Liang Chen Zhong-Cheng Xin Xin Li Long Tian Yi-Ming Yuan Gang Liu Xue-Jun Jiang Ying-Lu Guo

AIM To investigate the regulatory function of Cox7a2 on steroidogenesis and the mechanism involved in TM3 mouse Leydig cells. METHODS The cDNA of Cox7a2 was cloned from TM3 mouse Leydig cells. It was subcloned to pDsRed-Express-N1 and transfected back into TM3 mouse Leydig cells for Cox7a2 overexpression by transient gene transfection. Steroidogenesis affected by overexpressed Cox7a2 was stud...

2014
Trpimir Goluža Alexander Boscanin Jessica Cvetko Viviana Kozina Marin Kosović Maja Marija Bernat Miro Kasum Zeljko Kaštelan Davor Ježek

A number of studies have indicated that testicular macrophages play an important role in regulating steroidogenesis of Leydig cells and maintain homeostasis within the testis. The current paper deals with macrophages (CD68 positive cells) and Leydig cells in patients with nonobstructive azoospermia (NOA). Methods employed included histological analysis on semi- and ultrathin sections, immunohis...

2015
Salwan Maqdasy Laura Bogenmann Marie Batisse-Lignier Béatrice Roche Fréderic Franck Françoise Desbiez Igor Tauveron

49,XXXXY pentasomy or Fraccaro's syndrome is the most severe variant of Klinefelter's syndrome (KS) affecting about 1/85000 male births. The classical presentation is the triad: mental retardation, hypergonadotropic hypogonadism and radio ulnar synostosis. Indeed, the reproductive function of Fraccaro's syndrome is distinguished from KS. Besides, Leydig cell tumors are described in cases of KS,...

Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2002
A C S Castro W E Berndtson F M Cardoso

Plasma and tissue testosterone concentrations were determined by radioimmunoassay in 12 eight-month-old sexually mature New Zealand White rabbits and evaluated for possible associations with spermatogenic efficiency as well as with volume density and number of Leydig cells. Testicular tissue was processed histologically and histometry was performed in order to quantify germ cells, Sertoli cells...

Journal: :Urology journal 2009
Ioannis Efthimiou Charalampos Mamoulakis George Papageorgiou Sabbas Kazoulis Despina Prevedorou George Kontogiorgos Ioannis Christoulakis

Received October 2007 Accepted June 2008 INTRODUCTION Leydig cell tumors (LCTs) are the most common stromal tumors, accounting for 3% of all testicular neoplasms.(1) Approximately, 3% of the LCTs are bilateral.(1) They may be hormonally active, leading to either feminizing or virilizing syndromes. About 10% of them are malignant.(1) The diagnosis of a malignant LCT is not always easy, because n...

Journal: :PLoS ONE 2008
Jun Qin Ming-Jer Tsai Sophia Y. Tsai

Chicken Ovalbumin Upstream Promoter-Transcription Factor II (COUP-TFII; also known as NR2F2), is an orphan nuclear receptor of the steroid/thyroid hormone receptor superfamily. COUP-TFII-null mice die during the early embryonic development due to angiogenesis and cardiovascular defects. To circumvent the early embryonic lethality and investigate the physiological function of COUP-TFII, we knock...

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