Milner, R. D. G., Ross, J., Froud, D. J. R., and Davis, J. A. (1972). Archives of Disease in Childhood, 47, 927. Clinical pharmacology of gentamicin in the newborn infant. Newborn infants with suspected bacterial infection were treated with intramuscular gentamicin. Serum levels of the drug were measured 1 hour after the first dose, immediately before the second dose, and immediately before and...

OBJECTIVE To investigate whether transient-evoked and distortion-product (DP) otoacoustic emissions (OAEs) are more sensitive than pure-tone audiometry (PTA) in revealing gentamicin-induced ototoxicity in children with cystic fibrosis (CF). DESIGN Prospective case-control study. SETTING Tertiary referral audiologic center in conjunction with an academic pediatric CF unit. PARTICIPANTS The...

In the present study, we investigated the effects of the aqueous extract of Mucuna pruriens against gentamicin (100 mg kg -1 per day for six days) induced oxidative stress and nephrotoxicity in rats. Administration of gentamicin to rats induced a marked renal failure, characterized by a significant increase in urine volume and serum creatinine and urea levels. There was a significant decr...

OBJECTIVES One of the antidiabetic drugs, metformin, have shown that it prevented oxidative stress-induced death in several cell types through a mechanism involving the opening of the permeability transition pore and cytochrome c release. Thus, it is possible that the antioxidative effect of metformin can also serve as protection against gentamicin-induced cytotoxicity related to reactive oxyge...

High-level resistance to gentamicin was studied in seven clinical isolates of Enterococcus hirae. In common with other members of the genus Enterococcus, such resistance in E. hirae was associated with single, large, conjugative plasmids. Molecular genetic analysis revealed five distinct plasmid types amongst the seven isolates. The determinant mediating high-level gentamicin resistance in E. h...

This study was carried out to evaluate the protective effects of polyherbal extract against gentamicin induced renal injury in rats. 36 male Wistar rats were divided into six groups. Gentamicin administered (100 mg/kg, intraperitoneally for 10 d) all groups except normal control group. Polyherbal three (gentamicin+polyherbal 100 gentamicin+polyherbal 200 mg/kg and 300 mg/kg) at 100, body weight...

INTRODUCTION Osteitis is one of the most serious complications in orthopedic surgery. Expert Tibia Nail (ETN) PROtect™ coated with a biodegradable layer of gentamicin-laden polymer was developed for prophylaxis of osteomyelitis. In systemic administration, gentamicin has only a small therapeutic index and serious side effects; it is potentially nephrotoxic as well as ototoxic. It is not yet kno...

in the present study, we investigated the effects of the aqueous extract of mucuna pruriens against gentamicin (100 mg kg -1 per day for six days) induced oxidative stress and nephrotoxicity in rats. administration of gentamicin to rats induced a marked renal failure, characterized by a significant increase in urine volume and serum creatinine and urea levels. there was a significant decrease i...

Enterococcus faecalis LC40 is an ampicillin-susceptible clinical isolate with high-level gentamicin resistance due to the aac(6')-Ie-aph(2")-Ia aminoglycoside resistance gene. The combination of ampicillin plus arbekacin reduced mean bacterial vegetation counts significantly more than ampicillin alone or ampicillin plus gentamicin in a rabbit model of aortic-valve endocarditis caused by E. faec...