OBJECTIVE Oral fluoropyrimidine plus cisplatin is a standard treatment for advanced gastric cancer, but patients with severe peritoneal metastasis often cannot tolerate this regimen. The aim of this study was to assess the feasibility of fluorouracil, l-leucovorin and paclitaxel therapy in such patients. METHODS In the first phase of the study, we investigated the maximum tolerated dose and r...

Multiple studies have shown that leucovorin-fluorouracil regimens are modestly superior to fluorouracil alone in the treatment of advanced colorectal cancer. Laboratory data suggest that iododeoxyuridine could further enhance the efficacy of leucovorin-fluorouracil regimens. This report describes the Phase I clinical evaluation of a leucovorin-fluorouracil-iododeoxyuridine chemotherapy regimen....

At present, the global incidence of colorectal cancer is increasing, with numerous individuals succumbing to the disease. The standard treatment strategy for colorectal cancer is curative resection. However, a cure is rarely achieved for metastatic colorectal cancer. Currently, chemotherapy is the main treatment for metastatic and recurrent colorectal cancer. The majority of metastases or recur...

Herein we present a historical review of the development of systemic chemotherapy for colorectal cancer (CRC) in the metastatic and adjuvant treatment settings. We describe the discovery of 5-fluorouracil (5-FU) by Heidelberger and colleagues in 1957, the potentiation of 5-FU cytotoxicity by the reduced folate leucovorin, and the advent of novel cytotoxic agents, including the topoisomerase I i...

The sequential combination of methotrexate (MTX) followed by 5-fluorouracil (5-FUra) was evaluated. We treated 26 pa tients with 101 courses of high-dose MTX and minimal leucovorin rescue plus 5-FUra. MTX, 1.0 g/sq m, was administered as an 18-hr infusion. Three doses of leucovorin were given i.v. at Hours 30, 36, and 42 following the start of the MTX infusion. Leucovorin dosages were individua...

The sequential combination of methotrexate (MTX) followed by 5-fluorouracil (5-FUra) was evaluated. We treated 26 pa tients with 101 courses of high-dose MTX and minimal leucovorin rescue plus 5-FUra. MTX, 1.0 g/sq m, was administered as an 18-hr infusion. Three doses of leucovorin were given i.v. at Hours 30, 36, and 42 following the start of the MTX infusion. Leucovorin dosages were individua...

1 Abad A, Garcia P, Gravalos C, et al. Sequential methotrexate, 5-fluorouracil (5-FU), and high dose leucovorin versus 5-FU and high dose leucovorin versus 5-FU alone for advanced colorectal cancer. A multi-institutional randomized trial. Cancer 1995; 75: 1238–44. 2 Ajani JA, Kanojia MD, Bedikian AY. High-dose methotrexate and 5-fluorouracil in patients with advanced colorectal carcinoma. A ran...

The calcium leucovorin assay was improved by adding THORAL germicide which resuspended the cells so that an accurate turbidity reading could be obtained.