A double-blind placebo trial has been undertaken on 199 elderly patients admitted to an "acute" geriatric assessment ward. Clinical and biochemical assessment was made on admission (0) and at 2, 4, 8, 16 and 24 weeks (after admission). Ninety-four patients were supplemented with vitamin C (200 mg per day) and 105 had placebo tablets. Biochemical assessment included estimations of plasma and leu...

In the majority of patients receiving multiple transfusions, non-haemolytic febrile transfusion reactions (NHFTR) are caused by leucocyte antibodies. The severity of the reaction depends mostly on the absolute number of leucocytes present in the transfused blood as well as on the titre and the type of antibody in the recipient's plasma; the reaction can be prevented or alleviated by administrat...

1. The mechanism underlying the raised leucocyte sodium content in fulminant hepatic failure was studied by measurement of sodium fluxes, (Na+ + K+)-dependent adenosine triphosphatase activity, and leucocyte ATP content. 2. The rate constant for sodium efflux in the leucocytes was significantly reduced, and attributable to reduced activity of the enzyme (Na+ + K+)-ATPase. Leucocyte ATP content ...

We have detected new clues to the composition and function of "Transfer Factor" using the direct Leucocyte Migration Inhibition (LMI) test as an in vitro assay of Dialysates of Leucocyte Extracts (DLE). This approach has revealed two opposing antigen-specific activities to be present in the same > 3500 < 12,000 DA dialysis fraction - one activity is possessed of Inducer/Helper function (Inducer...

There was a conflicting result of previous studies about the correlation between anxiety and dialysis adequacy. The aim this study to evaluate association level with adequacy uncover age, leucocyte, hemoglobin in chronic kidney disease patients undergoing hemodialysis during Covid-19 pandemic. A cross-sectional conducted on 139 at hospital Semarang, Indonesia. measured by Hamilton Rating Scale ...

In this study leucocyte ascorbic acid concentrations and plasma ascorbic acid levels were measured simultaneously and correlation between these two variables was sought in various bacterial and viral infections. A total of 258 patients were studied. The control group consisted of 21 healthy children in the same age group. Except for scarlet fever no significant differences were observed between...

Two hundred and fifty cases of clinically suspected urinary tract infection were analysed for the detection of bacteriuria. Parameters studied included direct Gram staining, pyuria on microscopic examination of uncentrifuged urine and dip strip method for the detection of blood, protein, nitrite and leucocyte esterase. Significant bacteriuria (colony count 10(5) per ml) was found in 112 cases w...

Rapid mobilization of leucocytes through endothelial and epithelial barriers is key in immune system reactivity. The underlying mechanisms that regulate these processes have been the basis for many recent studies. Traditionally, leucocyte extravasation had been believed to occur through a paracellular route, which involves localized disruption of endothelial cell junctions. However, more recent...

IS THERE A ROLE FOR ROUTINE USE OF THE LEUCOCYTE ESTERASE TEST? Marrazzo et al have shown that, in a population screening strategy for chlamydia, the leucocyte esterase test on urine may reduce costs because of a reasonable negative predictive value. However, the positive predictive value of this test in asymptomatic men was only 20.1%. With a sensitivity similar to that of the smear (66.7% ver...

IS THERE A ROLE FOR ROUTINE USE OF THE LEUCOCYTE ESTERASE TEST? Marrazzo et al have shown that, in a population screening strategy for chlamydia, the leucocyte esterase test on urine may reduce costs because of a reasonable negative predictive value. However, the positive predictive value of this test in asymptomatic men was only 20.1%. With a sensitivity similar to that of the smear (66.7% ver...