We report the case of a 56-year old male with severe plaque psoriasis that was successfully treated with ixekizumab, a new anti interleukin (IL)-17 monoclonal antibody. During the first months of treatment he developed a lentiginous eruption in the sites of rapidly resolving plaques. Biopsy and immunohistochemistry reports showed elements of both lentigo and post-inflammatory hyper pigmentation...

1. Cerroni L, Wiesner T. Cutaneous lymphomas: from morphology to chip technology. Actas Dermosifiliogr. 2009;100S1: 3--17. 2. Cerroni L, Gatter K, Kerl H. Skin lymphoma: the illustrated guide. 3rd ed. Wiley-Blackwell: Chichester; 2009. 3. Zinzani PL, Ferreri AJ, Cerroni L. Mycosis fungoides. Crit Rev Oncol Hematol. 2008;65:172--82. 4. Berti E, Alessi E, Caputo R, Gianotti R, Delia D, Vezzoni P....

Lentigo maligna melanoma (LMM) is a slowly growing tumor of elderly white population. It typically develops on chronically sun-exposed skin of the head and neck area which indicates that the cumulative exposure to the UV radiation has crucial role in the development of LMM. Precursor lesion is lentigo maligna (LM) which commonly presents as an irregular brownish pigmented macular lesion persist...

1. Gage AA, Meenaghan MA, Natiella JR, Green GW Jr. Sensitivity of pigmented mucosa and skin to freezing injury. Cryobiology 1979; 16: 348 ± 361. 2. Zouboulis ChC. Principles of cutaneous cryosurgery: an update. Dermatology 1999; 198: 111 ± 117. 3. Almond-Roesler B, Zouboulis ChC. Milde Kryochirurgie zur Behandlung aktinischer Lentigines. Allergologie 1999; 21: 420 ± 421. 4. Stern RS, Dover JS,...

OBJECTIVE To assess outcomes in managing primary lentigo maligna through surgical excision, radiation therapy, and carbon dioxide laser ablation. METHODS Retrospective case series review of all patients with primary lentigo maligna diagnosed and treated in London, Ontario, Canada, between July 2, 1991, and June 29, 2010. RESULTS Seventy-five patients aged 39 to 93 years (mean age, 64.8 year...