La neurofibromatose de type 1(NF1) ou maladie de Von Recklinghausen est la plus fréquente des phacomatoses. C'est une affection autosomique dominante, où les mutations de novo concernent 50 % des patients. Son diagnostic est clinique avec des critères définis. Les manifestations cutanées arrivent au premier plan avec les taches café au lait (TCL), les lentigines axillaires et inguinales et les ...

Several pigment-specific lasers can effectively treat epidermal and dermal pigmented lesions without complications using the basic principles of selective photothermolysis. Although such pigmented lesions as solar lentigines and nevi of Ota are relatively easy to treat using pigment-specific laser technology, café-au-lait macules and melasma show variable responses to treatment. New, long-pulse...

LEOPARD syndrome, also known as Gorlin syndrome II, cardiocutaneous syndrome, lentiginosis profusa syndrome, Moynahan syndrome, was more recently coined as Noonan syndrome with multiple lentigines (NSML), inside the RASopathies. Historically, the acronym LEOPARD refers to the presence of distinctive clinical features such as: lentigines (L), electrocardiographic/conduction abnormalities (E), oc...

INTRODUCTION AND OBJECTIVES LEOPARD syndrome is an autosomal dominant condition related to Noonan syndrome, although it occurs less frequently. The aim of this study was to characterize the clinical and molecular features of a large series of LEOPARD syndrome patients. METHODS We collected clinical data from 19 patients in 10 hospitals. Bidirectional sequencing analysis of PTPN11, RAF1, and B...

OBJECTIVES To evaluate the frequency of misclassifications of equivocal pigmented lesions according to the first step of the dermatoscopic 2-step algorithm. PATIENTS AND METHODS 707 consecutive cases from 553 patients of central Europe and Australia were included in the study. Dermatoscopic images were evaluated in a blinded fashion for the presence of features described in the 2-step algorit...

1. Gage AA, Meenaghan MA, Natiella JR, Green GW Jr. Sensitivity of pigmented mucosa and skin to freezing injury. Cryobiology 1979; 16: 348 ± 361. 2. Zouboulis ChC. Principles of cutaneous cryosurgery: an update. Dermatology 1999; 198: 111 ± 117. 3. Almond-Roesler B, Zouboulis ChC. Milde Kryochirurgie zur Behandlung aktinischer Lentigines. Allergologie 1999; 21: 420 ± 421. 4. Stern RS, Dover JS,...

Epidemiologic research has shown that cutaneous markers of photo-damage are associated with risk of basal cell carcinoma (BCC). However, there has been no previous attempt to calculate pooled risk estimates. We conducted a systematic review and meta-analysis after extracting relevant studies published up to January 2013 from five electronic databases. Eligible studies were those that permitted ...

Familial lentiginosis syndromes cover a wide phenotypic spectrum ranging from a benign inherited predisposition to develop cutaneous lentigines unassociated with systemic disease, to associations with several syndromes carrying increased risk of formation of hamartomas, hyperplasias, and other neoplasms. The molecular pathways involved in the aetiology of these syndromes have recently been more...