نتایج جستجو برای: leishmanial activity

تعداد نتایج: 1134816  

Journal: :iranian biomedical journal 0
شیرین ملک زاده shirin malekzadeh حسین حسینی hossein hosseini هایده دارابی haiedeh darabi محمد حسین علی محمدیان mohammad hossein alimohammadian

partially purified antigenic fractions of leishmania major promastigotes were obtained by sodium dodecyl sulfate (sds-page) and electro-elution. three isolated protein fractions designated as frac tions (fr.) 1, 2, and 3 correspond to 40-60, 60-80, 80-100 kilodalton (kda) respectively. they were used for immunization of balb/c mice against leishmaniasis. the effects of these fractions on immune...

Journal: :Infection and immunity 1986
M S Giannini

The effects of suberythematous levels of UV-B radiation on the development of of cutaneous leishmaniasis were studied in B10.129(10M) mice. Doses of 15 mJ cm-2 UV-B applied locally to the injection site suppressed the development of skin lesions after the inoculation of Leishmania major promastigotes. The primary targets of UV-B radiation appeared to be host cells and not leishmanial parasites,...

Journal: :Molecules 2015
Jan Glaser Uta Schurigt Brian M Suzuki Conor R Caffrey Ulrike Holzgrabe

Bornyl caffeate (1) was previously isolated by us from Valeriana (V.) wallichii rhizomes and identified as an anti-leishmanial substance. Here, we screened a small compound library of synthesized derivatives 1-30 for activity against schistosomula of Schistosoma (S.) mansoni. Compound 1 did not show any anti-schistosomal activity. However, strong phenotypic changes, including the formation of v...

2013
Hamisi M Malebo Tanja Wenzler Monical Cal Sauda M Swaleh Maurice O Omolo Ahmed Hassanali Urs Séquin Daniel Häussinger Petur Dalsgaard Matthias Hamburger Reto Brun Isaiah O Ndiege

BACKGROUND Malaria, trypanosomiasis and leishmaniasis have an overwhelming impact in the poorest countries in the world due to their prevalence, virulence and drug resistance ability. Currently, there is inadequate armory of drugs for the treatment of malaria, trypanosomiasis and leishmaniasis. This underscores the continuing need for the discovery and development of new anti-protozoal drugs. C...

ژورنال: Medical Laboratory Journal 2017
Maroufi , Yahya, Dabirzadeh , Mansour , Miri , Abdolhossein , Noormohammadi , Hamed ,

ABSTRACT             Background and Objectives: Leishmaniasis is a public health problem caused by the protozoan Leishmania. Pentavalent antimonials are currently used for treatment of leishmaniasis, but they have serious side effects. Nerium oleander L. has been used in traditional medicine due to its various health-protective propertie...

2017
Elham MOGHADDAS Ali KHAMESIPOUR Mehdi MOHEBALI Abdolmajid FATA

BACKGROUND Chemotherapy still relies on the use of pentavalent antimonials, amphotericin B, paromomycin, miltefosin, and allopurinol. In this study, we explained about the native plant that grows in different regions of Iran and used as anti-leishmanial in Iran and even many other countries. METHODS This narrative review covers all information about local herbal medicine in Iran that used in ...

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