Hemodynamic data and systolic time intervals were obtained at resting heart rate and during atrial pacing in 10 patients with heart disease, eight with left ventricular dysfunction, and two with mitral stenosis. The mean increase in heart rate was 44 beats/min. During atrial pacing there was no significant alteration in cardiac output, minute work, left atrial or pulmonary wedge mean pressure, ...

It has been shown in man that myocardial ischemia, whether precipitated by exercise or pacinginduced tachycardia, is associated with abnormalities of left ventricular end-diastolic pressure. There has been controversy as to whether this relationship is due to decreased myocardial compliance or to an increase in left ventricular volume as a manifestation of left ventricular failure. Simultaneous...

Left ventricular function, pressure-volume relationships, and wall motion were studied by sequential cineventriculography during acute myocardial ischemia, induced by atrial pacing, in 10 subjects. Observations made in this group were contrasted to data obtained during atnal pacing in a smaller normal group. An acute alteration in the pressure-volume relation occurred in five subjects during is...

Study of left ventricular pressure-volume relations in man has been limited by technical problems associated with left ventricular angiography. A new approach to this problem using simultaneous recording of left ventricular pressure and left ventricular volume (determined by echocardiography) was applied in 21 patients. Pressure-volume plots, constructed from pressure and volume values sampled ...

Isovolumic relaxation abnormalities have been noted in the ischemic left ventricle, but altered end-diastolic distensibility, as well as the role of right ventricular distention, is debated. Accordingly, left ventricular end-diastolic pressure and myocardial segment length were studied in the open-chest dogs with critical (90% diameter reduction) stenoses on both left anterior descending and ci...

The hemodynamic effects of a new,/3 agonist, prenalterol, were studied in 13 patients with severe left ventricular failure (New York Heart Association functional class III or IV). Seven patients had ischemic heart disease and six congestive cardiomyopathy. Left ventricular function was studied by catheter-tip manometer measurements of left ventricular pressure and simultaneous pressure-volume a...

Catheterization of the left heart permits sophisticated assessment of the mechanical problem in aortic stenosis. Selection of patients for surgical repair requires an additional judgment regarding the contractile state of the left ventricle. Angiotensin has recently been used to study the function of the unobstructed left ventricle by imposing controlled pressure loads on both compensated and f...

Left ventricular function, pressure-volume relationships, and wall motion were studied by sequential cineventriculography during acute myocardial ischemia, induced by atrial pacing, in 10 subjects. Observations made in this group were contrasted to data obtained during atnal pacing in a smaller normal group. An acute alteration in the pressure-volume relation occurred in five subjects during is...

A seven-year-old girl with clinical diagnosis of aortic insufficiency underwent echocardiographic and hemodynamic evaluation and referred for surgery with the same diagnosis. However, at surgery, aorto-Ieft ventricular tunnel was found and repaired successfully. Review of echocardiogram and catheterization data revealed interesting findings to differentiate this rare entity from congenital...

The relation between the left atrial systolic pressure waveform and left ventricular end-diastolic pressure was observed in 17 patients who underwent diagnostic cardiac catheterization. Left atrial pressure and left ventricular pressure were simultaneously recorded from a multisensor catheter before and during angiotensin infusion. Left ventricular systolic pressure and left ventricular end-dia...