The heterocyclic N-oxide, 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine, 1), shows promising antitumor activity in preclinical studies, but there is a continuing need to explore new compounds in this general structural category. In the work described here, we examined the properties of 7-chloro-2-thienylcarbonyl-3-trifluoromethylquinoxaline 1,4-dioxide (9h). We find that 9h causes redox...

Supply chain management (SCM) addresses the management of materials and information across the entire chain from suppliers to producers, distributors, retailers, and customer. The theory of supply chain management suggests that lead time reduction is a pioneer to the use of market mediation to reduce transaction uncertainty in the chain, which can be conceptualized as the primary goal of supply...

this article presents a new subspace-based technique for reducing the noise ofsignals in time-series. in the proposed approach, the signal is initially representedas a data matrix. then using singular value decomposition (svd), noisy datamatrix is divided into signal subspace and noise subspace. in this subspace division,each derivative of the singular values with respect to rank order is used ...

I examine whether working hours have a causal effect on the health behaviors of workers. In assessing the causal relationship, I estimate fixed-effects instrumental variable models by using exogenous variation in adopting a reduced workweek in South Korea as an instrument for work hours. The estimation results reveal that shortening work hours induces individuals to exercise regularly and decre...

Manufacturing operations were studied at a semiconductor capital equipment manufacturing plant, with an aim to reduce the production time of their longest lead time module. Preliminary analysis was done by observing the assembly and test operations on the production floor, and material handling operations at the warehouse. Detailed time studies were then performed on the assembly and test proce...

LEAN THINKING FOR LEAD-TIME REDUCTION AND EFFICIENT KNOWLEDGECREATION IN PRODUCT DEVELOPMENT DOMAINby

response surface methodology was applied to determine the optimum processing conditions that lead to maximum water loss, weight reduction and minimum solid gain as well as water activity during osmotic dehydration of carrots. temperature (30-50?c), processing time (120-240 min), glucose syrup de=42 (30-50% w/w) and salt (5-15%) concentrations were the factors investigated with respect to water ...