نتایج جستجو برای: lca
تعداد نتایج: 5062 فیلتر نتایج به سال:
Today, along with the increasing environmental awareness in the politic, public and industries, the demand on environmentally friendly products and technologies has been increasing. Therefore within the research and development of a product or technology in industries as well as in national or international funded R&D activities the method of Life Cycle Assessment (LCA) is often implemented in ...
Bile acids are steroid detergents that are toxic to mammalian cells at high concentrations; increased exposure to these steroids is pertinent in the pathogenesis of cholestatic disease and colon cancer. Understanding the mechanisms of bile acid toxicity and apoptosis, which could include nonspecific detergent effects and/or specific receptor activation, has potential therapeutic significance. I...
In this paper we seek to describe the structure of self-dual torsion-free LCA groups. We first present a proof of the structure theorem of self-dual torsion-free metric LCA groups. Then we generalize the structure theorem to a larger class of selfdual torsion-free LCA groups. We also give a characterization of torsion-free divisible LCA groups. Consequently, a complete classification of self-du...
Littoral cell angioma (LCA) is a rare benign tumour of the spleen. We describe a patient with aplastic anaemia who, following multiple treatments with rabbit and horse Anti-Thymocyte Globulin and anabolic steroids developed marked splenomegaly and hypersplenism. LCA was diagnosed post splenectomy. This is the first case of LCA associated with aplastic anaemia and its treatment.
Longitudinal Chromatic Aberration (LCA) influences the optical quality of the eye. However, the reported LCA varies across studies, likely associated to differences in the measurement techniques. We present LCA measured in subjects using wavefront sensing, double-pass retinal images, and psychophysical methods with a custom-developed polychromatic Adaptive Optics system in a wide spectral range...
PURPOSE To test the efficiency of a microarray chip as a diagnostic tool in a cohort of northwestern European patients with Leber congenital amaurosis (LCA) and to perform a genotype-phenotype analysis in patients in whom pathologic mutations were identified. METHODS DNAs from 58 patients with LCA were analyzed using a microarray chip containing previously identified disease-associated sequen...
PURPOSE To test patients from southern India for the presence of mutations that most commonly cause Leber congenital amaurosis (LCA) in northern America. METHODS A review of the literature identified 177 unique LCA causing mutations in eight different genes: aryl hydrocarbon receptor interacting protein-like 1 (AIPL1), crumbs homolog 1 (CRB1), cone-rod homeobox (CRX), guanylate cyclase 2D (GU...
PURPOSE Leber congenital amaurosis (LCA) is an early-onset inherited disorder of childhood blindness characterized by visual impairment noted soon after birth. Variants in at least six genes (AIPL1, CRB1, CRX, GUCY2D, RPE65, and RPGRIP1) have been associated with a diagnosis consistent with LCA or early-onset retinitis pigmentosa (RP). Genetically heterogeneous inheritance complicates the analy...
Bile acids induce apoptosis selectively in androgen-dependent and -independent prostate cancer cells
Prostate cancer is a prevalent age-related disease in North America, accounting for about 15% of all diagnosed cancers. We have previously identified lithocholic acid (LCA) as a potential chemotherapeutic compound that selectively kills neuroblastoma cells while sparing normal human neurons. Now, we report that LCA inhibits the proliferation of androgen-dependent (AD) LNCaP prostate cancer cell...
Quantifying and reducing uncertainty in life cycle assessment using the Bayesian Monte Carlo method.
The traditional life cycle assessment (LCA) does not perform quantitative uncertainty analysis. However, without characterizing the associated uncertainty, the reliability of assessment results cannot be understood or ascertained. In this study, the Bayesian method, in combination with the Monte Carlo technique, is used to quantify and update the uncertainty in LCA results. A case study of appl...
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