Many connective tissue diseases are characterized by fatigue, which is described in the literature as prostration, weakness, lassitude or asthenia. In many other diseases (autoimmune, neurologic or metabolic) fatigue impinges on daily activities and thus influences the quality of life. Different molecular backgrounds are involved in the development of fatigue. Not only does the immunosuppressiv...

We report a juvenile case of diffuse sclerosing osteomyelitis of the mandible that showed a favorable response to pamidronate, a bisphosphonate derivative. Although conventional treatments had been ineffective for 5 years, pamidronate administration brought about conspicuous improvement both clinically and radiographically. Severe adverse reaction was not found except for low-grade fever and la...

This paper reviews studies that have examined associations between unusual sleep experiences (including nightmares, vivid dreaming, narcolepsy symptoms, and complex nighttime behaviors) and dissociation and schizotypy. Using correlational studies and structural analyses, evidence is provided that unusual sleep experiences, dissociation, and schizotypy belong to a common domain. It is demonstrat...

At any point 1-5 days following ascent to altitudes ≥2500 m, individuals are at risk of developing one of three forms of acute altitude illness: acute mountain sickness, a syndrome of nonspecific symptoms including headache, lassitude, dizziness and nausea; high-altitude cerebral oedema, a potentially fatal illness characterised by ataxia, decreased consciousness and characteristic changes on m...

BACKGROUND Many patients are undernourished during hospitalisation. The clinical consequences of this include lassitude, an increased risk of complications and prolonged convalescence. The aim of the study is 1) to implement a new organisation with a focus on improving the quality of the nutritional care of medical inpatients at risk of undernutrition, and 2) to investigate the effect of the in...

this is a letter to editor.There is growing interest in the health benefits of botanical diuretics. (1-2) ‎Avicenna (980-1037 AD), the foremost Iranian physician,‎‏ ‏introduced ‎numerous herbs as diuretics in his renowned book of Canon of Medicine. (3)‎Avicenna and his followers have recommended herbal diuretics for most ‎ailments accompanied by fluid superabundance like lassitude, oedema, and ...

Zolpidem is widely prescribed in clinical practice for the treatment of sleep disorders and it is generally considered safe and well tolerated. However, several cases of hallucinations, amnesia, and delirium associated with the use of zolpidem have been reported previously (Ansseau et al., 1992; Katz, 1995; Toner et al., 2000). We present an elderly woman who experienced visual hallucinations a...

BACKGROUND In depressed patients, low blood levels of eicosapentaenoic acid are seen. We tested the antidepressive effect of ethyl-eicosapentaenoate in these patients. METHODS We included 70 patients with persistant depression despite ongoing treatment with an adequate dose of a standard antidepressant. Patients were randomized on a double-blind basis to placebo or ethyl-eicosapentaenoate at ...

BACKGROUND Many patients do not eat and drink sufficiently during hospitalisation. The clinical consequences of this under nutrition include lassitude, an increased risk of complications and prolonged convalescence. The aim of the study was 1) to introduce intervention targeting nutritional care for medical inpatients, 2) to investigate the effect of this intervention, and 3) to investigate the...

This fictionalized script (fictional dialogue between Coronavirus and the Philosopher) traces contours of conversation that seeks to fathom crisis unleashed by outbreak global spread coronavirus (COVID-19 pandemic) ensuing anxieties created in our current social living. The scenario deepened isolation self from other (social distancing ‘stay-at-home’ or various lockdowns) is considered, it prop...