OBJECTIVE This study was conducted to evaluate the safety, tolerability, and pharmacokinetics (PKs) of different doses of a long-acting release (LAR) formulation of pasireotide in healthy subjects. DESIGN Single-center, open-label, randomized Phase I study. METHODS Twelve healthy male subjects received a single s.c. dose of pasireotide 300 μg followed by a washout period of 7 days (or at le...

BACKGROUND Advances in immunosuppression after kidney transplantation have decreased the influence of early acute rejection (EAR) on graft survival. Several studies have suggested that late acute rejection (LAR) has a poorer effect on long-term graft survival than EAR. We investigated whether the timing of acute rejection (AR) influences graft survival, and analyzed the risk factors for EAR and...

BACKGROUND Octreotide long-acting repeatable (LAR) is approved in the United States for the management of carcinoid syndromes among patients with neuroendocrine tumors (NET). The objective of our study is to evaluate the impact of octreotide LAR on overall survival (OS), as it has not been established. METHODS NET patients of 65 years and older diagnosed between January 1999 and December 2009...

OBJECTIVE This study compares 3 cohorts of patients with schizophrenia before, during, and after initiating treatment with fluphenazine decanoate (FD), haloperidol decanoate (HD), or long-acting injectable risperidone (LAR). METHODS Administrative data are analyzed from California Medicaid (Medi-Cal) beneficiaries with schizophrenia who initiated FD, HD, or LAR treatment. Patients were requir...

Mesenchymal stem cells (MSCs) are multipotent adult stem cells that can differentiate into a variety of mesodermal-lineage cells. MSCs have significant potential in tissue engineering and therapeutic applications; however, the low differentiation and proliferation efficiencies of these cells in the laboratory are fundamental obstacles to their therapeutic use, mainly owing to the lack of inform...

The location-aided routing scheme 1 (LAR-1) and probabilistic algorithms were combined together into a new algorithm for route discovery in mobile ad hoc networks (MANETs) called (LAR-1P) [1]. Simulation results demonstrated that, on network scale, for a uniform random node distribution and for a specific simulation setup (time); the LAR-1P algorithm reduces the number of retransmissions as com...

In this paper, we study the performance of two important types of decode–and–forward (DF) relaying schemes proposed for cooperative diversity (CD) systems, namely, cooperative maximum–ratio combining (C–MRC) and link adaptive regeneration (LAR). In particular, we provide a unified framework for the error rate performance analysis of C–MRC, LAR–αinst, and LAR–α DF schemes for multi–branch CD sys...

Drosophila and leech models of nervous system development demonstrate that protein tyrosine phosphatase (PTP) receptors regulate developmental neurite outgrowth. Whether PTP receptors regulate neurite outgrowth in adult systems or in regenerative states remains unknown. The leukocyte common antigen-related (LAR) receptor is known to be present in rodent dorsal root ganglion (DRG) neurons; there...

BACKGROUND Long-acting sandostatin (S-LAR; octreotide acetate) is well tolerated and effective for symptom control and possibly disease control in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). We undertook a retrospective analysis to study the efficacy and tolerability of higher doses (more than 20-30 mg/month) of S-LAR in GEP-NETs. PATIENTS AND METHODS With IRB approval, charts of...