The rapidly increasing prevalence of childhood obesity and its associated co-morbidities such as hypertriglyceridemia, hyper-insulinemia, hypertension, early atherosclerosis, metabolic syndrome, and non-alcoholic fatty liver disease are major public health concerns in many countries. Therefore the trends in child and adolescent obesity should be closely monitored over time, as in the near futur...

conclusion the prevalence of nafld in this group of iranian adult general population is 21.5%. nafld in iranian population is associated with male gender, old age, obesity, and features of metabolic syndrome. results 819 subjects were included in this study among which were 340 males (41.5%) and 479 females (58.5%) with the mean age of 43.1 ± 14.1 years. nafld was diagnosed in 176 (21.5%) subje...

conclusions lepr q223r polymorphisms may confer a significant risk of nafld and coronary atherosclerosis. the a allele in the k109r polymorphism might be considered an independent risk factor for coronary atherosclerosis in nafld patients. objectives to investigate the association of lepr polymorphisms at q223r and k109r with the risks of nafld and coronary atherosclerosis in the chinese han po...

results although a hypocaloric diet could prevent the progression of fat accumulation in liver, the diet composition is another aspect which should be considered in diet therapy of patients with nafld. conclusions several studies assessed the effects of dietary composition on fat storage in liver; however, their findings are inconsistent. most studies focused on the quantity of carbohydrate and...

Non-alcoholic fatty liver disease is a serious health problem linked to obesity and type 2 diabetes. To investigate the biological outcome and therapeutic potential of hepatic fatty acid uptake inhibition, we utilized an adeno-associated virus-mediated RNA interference technique to knock down the expression of hepatic fatty acid transport protein 5 in vivo prior to or after establishing non-alc...

background :timely diagnosis of liver cirrhosis is vital for preventing further liver damage and giving the patient the chance of transplantation. although biopsy of the liver is the gold standard for cirrhosis assessment, it has some risks and limitations and this has led to the development of new noninvasive methods to determine the stage and prognosis of the patients. we aimed to design an a...

Sodium glucose cotransporter 2 inhibitors are expected to ameliorate the abnormalities associated with metabolic syndrome including non-alcoholic fatty liver disease. In this study, we investigated the effects of the sodium glucose cotransporter 2 inhibitor tofogliflozin on the development of non-alcoholic fatty liver disease-related liver tumorigenesis in C57BL/KsJ-+Lepr db /+Lepr db obese and...

AIM The aim of this study was to review cases of non-alcoholic fatty liver disease cases and to determine the prevalence of non-alcoholic fatty liver disease as a cause of elevated alanine aminotransferase in healthy blood donors in the Permian area and also assess risk factors of NAFLD such as BMI and correlation with metabolic syndrome in these subjects. BACKGROUND Non-alcoholic fatty liver...

conclusions in the chinese han population that we studied, nafld patients who carry the tnf-α-238 ga polymorphism have an increased risk of developing cad. mechanisms underlying this potentially important association require further investigation. background cardiovascular events account for the main cause of death in patients with non-alcoholic fatty liver disease (nafld), and are largely infl...

background: non-alcoholic fatty liver disease (nafld) is characterized by fatty change of liver without inflammation. the aim of this study was to evaluate presence of clinical and metabolic components in non-diabetic patients with nafld and to assess the relationship between insulin resistance and these factors. materials andmethods: in this study, a group of 50 sonographically confirmed patie...