~Ihe nature of Langerhans cells is disputed. ~fhey have been considered effete melanocytes (1, 2), postmelanin-synthetic cells (3), melanocyte precursors (4), intraepidermal nerve endings (5, 6), or postdivisional stages of previously melanogenic melanocytes (7). Under the electron microscope, melanocytes and Langerhans cells are distinguished by highly characteristic cytoplasmic or-ganelles: m...

localized leishmania lymphadenitis (l.l.l) is a self limited clinical presentation of cutaneous leishmaniasis. microscopic findings in l.l.l are very similar to toxoplasma lymphasenitis. in all cases, an intensive microscopic search should be done for leishman bodies. in this study, we describe our microscopic findings and results of our immnohistochemical (ihc) study with a panel of monoclonal...

histiocytosis of langerhans cells (class 1 histiocytosis) consists of a range of clinical manifestations, including bone eosinophilic granuloma, hand-schüller-christian syndrome, and letterer-siwe disease. these syndromes represent a spectrum of severity and prognosis of an underlying disorder which is usually sporadic. this report describes three cases in one family, who developed the disease ...

Four neonates had solitary, congenital, rapidly growing, spontaneously ulcerating tumors of the face, trunk, and extremities. No extracutaneous involvement was found, and all lesions spontaneously involuted. Mononuclear cells of the cutaneous infiltrate were Langerhans' cells. These findings expand the spectrum of congenital self-healing reticulohistiocytosis. The Langerhans' cells (LC), dendri...

background: the langerhans cells (lcs) are dendritic cells (dcs) which belong to the group of antigen presenting cells (apcs). their function is to recognize the antigen, capture it, and present it to the t lymphocytes; thus initiating an early immune response. the antigen presenting functional lcs may play an important part in initiation and development of gingivitis. the aim of this study was...

A morphometric analysis of tumoral Langerhans cells and activated macrophages was conducted using canine cutaneous tumors (65 cases of canine cutaneous histiocytoma and 7 cases of pyogranuloma). The histiocytic origin of the tumor cells was confirmed using immunohistochemistry. The parameters of the morphometric analysis included cellular and nuclear size and shape and the nuclear:cytoplasmic r...

BACKGROUND Calcifying epithelial odontogenic tumour (CEOT) is a rare benign odontogenic tumour, and its Langerhans cell variant is even rarer. Due to the limited number of recorded cases, the biological behaviour and histogenesis of the Langerhans cell variant of CEOT are not yet fully understood. Thus, the correlation between conventional CEOT and the Langerhans cell variant remains to be clar...

Our study aims at characterizing 3D nuclear architecture of distinct sub-populations epidermal cells. We have performed FISH & RASER-FISH, combined with immunofluorescence and analysis widefield SIM super-resolution on cryosections cultured Organization the nucleus significantly differs between cell types during differentiation. Previous studies showed that heratinocyte(KC) differentiation is a...

Localized Leishmania Lymphadenitis (L.L.L) is a self limited clinical presentation of cutaneous leishmaniasis. Microscopic findings in L.L.L are very similar to Toxoplasma lymphasenitis. In all cases, an intensive microscopic search should be done for Leishman bodies. In this study, we describe our micro...