Murine epidermal Langerhans cells were analyzed with fluorescence microscopy and multicolor flow cytometry for the surface expression of major histocompatibility complex (MHC) class I and class II antigens. Langerhans cells of H-2k haplotype were identified in situ or in epidermal-cell suspensions by their surface expression of the MHC class II determinants I-Ak and I-Ek. More than 90% of class...

Langerhans' cell histiocytosis summarizes a spectrum of diseases on the basis of histogenetic criteria. These are characterized by an accumulation of cells with Langerhans' cell phenotype in one or multiple organs. Up to 50% of patients with either single or multi-organ manifestation of Langerhans' cell histiocytosis initially present with cutaneous symptoms. Nevertheless, cutaneous Langerhans'...

1. Querings K, Starz H, Balda BR. Clinical spectrum of cutaneous Langerhans’ cell histiocytosis mimicking various diseases. Acta Derm Venereol 2006;86:39-43. 2. Stein SL, Paller AS, Haut PR, Mancin AJ. Langerhans cell histiocytosis presenting in the neonatal period: A retrospective case series. Arch Pediatr Adolesc Med 2001;155:778-83 3. Punia RS, Bagai M, Mohan H, Thami GP. Langerhans cell his...

Langerhans cells are antigen presenting dendritic cells and tumours arising from these are rare. The tumours arising from these dendritic cells are divided into two categories according to a WHO classification: Langerhans cell histiocytosis and Langerhans cell sarcoma. It is the degree of atypia and clinical aggressiveness that distinguishes the two subtypes. Langerhans cell sarcoma (LCS) is a ...

Langerhans' cell histiocytosis of the lung can be part of a multisystem disorder or an isolated disorder. Ninety percent of adult patients with Langerhans' cell histiocytosis of the lung are smokers. This article reports a case of Langerhans' cell histiocytosis presenting with haemoptysis. The diagnostic signs on chest X-ray, high-resolution computed tomography, and histology are highlighted, f...

Langerhans’ cell histiocytosis may cause irreversible respiratory failure due to progressive destruction of lung parenchyma and widespread cystic change. Transplantation oVers a therapeutic option. A case is described of recurrence of Langerhans’ cell histiocytosis which was associated with deterioration in lung function four years following bilateral lung transplantation. Patients transplanted...

BACKGROUND It was shown earlier that a number of CD207 positive Langerhans cells was lower in basal cell carcinomas than in the normal epidermis. Moreover, benign skin lesions presented a higher number of Langerhans cells when they were compared to malignant tumors. AIM To count Langerhans cells, assessing expression levels of CD1A and CD207 markers in actinic keratosis, basal and squamous ce...

background: langerhans' cell histiocytosis (lch) is a reactive proliferative disease of unknown pathogenesis characterized by proliferation of langerhans cells. involvement of bone marrow (bm), liver and lung are related to high risk factors and poor survival. the aim of this report is to highlight the clinical and haematological findings of 5 cases of lch with bm infiltration which may help to...

<p class="abstract">Langerhans cell histiocytosis is a condition of exceptional onset characterized by proliferative event dendritic cells with mono or multisystem involvement that predominates in the pediatric population and identified smaller proportion adults. It has clinical impact variable prognosis according to its location number organs affected. A 68-year-old male patient immunohi...