INTRODUCTION Over the past decade the use of lamotrigine in bipolar disorder has increased. However, the evidence base suggests a more limited role for lamotrigine as part of an overall treatment regimen in bipolar disorder. AREAS COVERED We reviewed publications of randomized clinical trials of lamotrigine, emphasizing studies in bipolar disorder. The low burden of adverse effects with lamot...

A wide variety of movement disorders can be induced by the administration of antiepileptic drugs. A 44-year-old female was admitted with involuntary excessive eye blinking that manifested 5 months after beginning the administration of lamotrigine for control of complex partial and secondarily generalized seizures. The involuntary eye blinking persisted while taking lamotrigine, and disappeared ...

A 55-year-old female with no physical problems was initially hospitalized for psychotic mania but soon discharged. A month later she was rehospitalized for bipolar depression and treated with lamotrigine (25 mg/day), olanzapine (10 mg/day), and lorazepam (0.5 mg/day). On day 22, lamotrigine was stopped because of neutropenia. On the same day, the patient developed skin rashes with pruritus, whi...

Stevens-Johnsons Syndrome (SJS) is an immune-complex-mediated hypersensitivity reaction and has been linked as an adverse side effects to many drugs. Lamotrigine, an anticonvulsive medication and also a commonly used mood stabiliser, can be associated with this adverse reaction. Although this has not been reported very commonly , SJS has high mortality and morbidity and requires careful attenti...

Lamotrigine is an antiepileptic drug widely used to control seizures. It has many adverse events but in rare instances, it can cause hypersensitivity syndrome (DHS). We describe a case of lamotrigine induced characterized by febrile erythema and eosinophilia. The suspect was replaced valproate leading marked improvement.

OBJECTIVES CEQUEL (Comparative Evaluation of QUEtiapine plus Lamotrigine combination versus quetiapine monotherapy [and folic acid versus placebo] in bipolar depression) was a double-blind, randomized, placebo-controlled, parallel group, 2×2 factorial trial that examined the effect of adding lamotrigine and/or folic acid (FA) to quetiapine in bipolar depression. Lamotrigine improved depression,...

Pharmacovigilance presents many challenges, particularly when managing unpredictable, rare conditions, eg, severe cutaneous adverse reactions (SCARs). Such rare events are often only detected from spontaneous reports, which present their own limitations, particularly during a prolonged global launch schedule. GlaxoSmithKline's routine pharmacovigilance includes regular reviews of global adverse...

PURPOSE Controlled randomized studies recommending the clinical use of lamotrigine in adult populations with the diagnosis of Juvenile Myoclonic Epilepsy are still lacking. To compare the efficacy and tolerability of lamotrigine versus valproate in adult patients with JME. METHODS This was a prospective, randomized, controlled, pragmatic, long-term and open-label treatment trial. Patients wer...

Glial cells play a critical role in morphine tolerance, resulting from repeated administration of morphine. Both the development and the expression of tolerance are suppressed by the analgesic lamotrigine. This study investigated the relationship between the ability of lamotrigine to maintain the antinociceptive effect of morphine during tolerance development and glial cell activation in the sp...

Lamotrigine is an antiepileptic drug used as a treatment for partial and generalised seizures as well as for bipolar disorder type I. Till date, very few cases of lamotrigine overdose have been reported. The spectra of clinical effects of lamotrigine in acute overdose are not well established. In severe cases of poisoning, serious effects such as coma, respiratory depression, recurrent seizures...