This review discusses one of the most relevant problems in gastrointestinal clinical practice: lactose intolerance. The role of lactase-persistence alleles the diagnosis of lactose malabsorption the development of lactose intolerance symptoms and its management. Most people are born with the ability to digest lactose, the major carbohydrate in milk and the main source of nutrition until weaning...

A wild-type strain of Klebsiella oxytoca growing aerobically in batch culture has exhibited intermittent or oscillatory growth while growing on lactose at concentrations on the order of 1 g/L or less. In two-substrate experiments, preferred growth on glucose followed by growth on lactose also produced oscillatory growth behavior during the lactose growth phase at lactose concentrations of 1 g/L...

The incidence of lactose malabsorption was investigated in 85 patients with ulcerative colitis and 71 patients with Crohn's disease by means of lactose tolerance tests and disaccharidase determinations in small intestinal mucosa. Eight patients with ulcerative colitis (9%) and four with Crohn's disease (6 %) had lactose malabsorption. A control group displayed a similar incidence. It is conclud...

The lactose hydrogen breath test is a commonly used, non-invasive method for the detection of lactose malabsorption and is based on an abnormal increase in breath hydrogen (H₂) excretion after an oral dose of lactose. We use a combined (13)C/H₂ lactose breath test that measures breath (13)CO₂ as a measure of lactose digestion in addition to H₂ and that has a better sensitivity and specificity t...

Lactose intolerance related to primary or secondary lactase deficiency is characterized by abdominal pain and distension, borborygmi, flatus, and diarrhea induced by lactose in dairy products. The biological mechanism and lactose malabsorption is established and several investigations are available, including genetic, endoscopic and physiological tests. Lactose intolerance depends not only on t...

The incidence of lactose malabsorption was investigated in 85 patients with ulcerative colitis and 71 patients with Crohn's disease by means of lactose tolerance tests and disaccharidase determinations in small intestinal mucosa. Eight patients with ulcerative colitis (9%) and four with Crohn's disease (6 %) had lactose malabsorption. A control group displayed a similar incidence. It is conclud...

The purpose of this study was to determine the lactose behaviour during partial crystallisation in spray drying. Spray-dried lactose has been widely used in pharmaceutical industries as excipient for dry powder inhalation drugs. Partial crystals of lactose were produced by spray-dried lactose solutions at different operating condition of inlet temperature, feed flow rate and sample concentratio...

Mutative lactose fermentation of lactose negative strains of Klebsiella pneumoniae to the lactose positive condition has been reported by Henriksen (1950) and Cabelli and Pickett (1953). The latter workers also demonstrated that the ability to ferment lactose was associated with a faster growth rate and with a greater resistance to the bacteriostatic action of the dye brilliant green, to the in...

Lactose is a prominent sugar found in all diary products, as well as in mother's milk. Lactose maldigestion/intolerance is the term used to describe the inability to digest lactose in milk and milk products, producing symptoms of intestinal gas, abdominal distension, and flatulence with loose, watery, acidic diarrhea.Adverse reactions to the lactose portion of milk are primarily related to the ...

The concept of lactose intolerance has become embedded in Western medicine and developing economy medicine. It is based on evidence that intestinal lactase activity persists into later childhood and throughout life in only a minority of the world's population, notably northern European-derived populations. These people have the T single nucleotide polymorphism (SNP) of the rs49882359 allele (C/...