This work addresses the problem of visualizing hardly formalized relations i.e. connections between distributed collaborating experimenters. These dependencies are not measurable and hard to determine. It is proposed to determine the relations using the measurable and determinable connections between software agents acting on behalf of the users. A connection between the agents is treated as th...

—This paper presents the solar energy e-learning laboratory, developed at the Higher Technical Institute (HTI) within the framework of the Leonardo da Vinci project MARVEL, focuses on the system architecture and its features, and elaborates on the learning platform employed. The laboratory focuses on experiential based learning-arrangements allowing remote and distributed training with the labo...

BACKGROUND Techniques for interim analysis, the statistical analysis of results while they are still accumulating, are highly-developed in the setting of clinical trials. But in the setting of laboratory experiments such analyses are usually conducted secretly and with no provisions for the necessary adjustments of the Type I error-rate. DISCUSSION Laboratory researchers, from ignorance or by...

The purpose of this study was to determine the effect of investigative laboratory integration on student content knowledge and science process skill achievement across learning styles. Treatment groups utilized one of three levels of treatment: subject matter approach without laboratory experimentation, subject matter approach with prescriptive laboratory experimentation, and subject matter app...

The current reliance on the use of the Mouse Bioassay to detect shellfish biotoxins in national shellfish safety programmes in Europe means that there are regulatory aspects that potentially conflict between food hygiene and animal experimentation legislation. In the United Kingdom, the use of animals for any scientific purpose requires authorisation under the Animals (Scientific Procedures) Ac...

Pesticides have provided significant benefits including plant disease control and increased crop yields since people developed and utilized them. However, pesticide use is associated with many adverse effects, which necessitate precise toxicological tests and risk assessment. Most of these methods are based on animal studies, but considerations of animal welfare and ethics require the developme...

Single-laboratory studies conducted under highly standardized conditions are the gold standard in preclinical animal research. Using simulations based on 440 preclinical studies across 13 different interventions in animal models of stroke, myocardial infarction, and breast cancer, we compared the accuracy of effect size estimates between single-laboratory and multi-laboratory study designs. Sin...

Field primatologists face unusual ethical issues. We study animals rather than people and receive research approval from animal care rather than ethics committees. However, animal care evaluation forms are developed from concerns about laboratory animal research and are based on the "Three R's" for humane treatment of captive experimental subjects (replacement, reduction and refinement), which ...

Law 11794 establishes procedures for the scientific use of animals and abrogates the previous Law 6638/1979, which was ineffective because it was not regulated by the Brazilian Executive Power. Without regulation, many issues remained ill-defined, including operational procedures and responsibilities such as licensing, accreditation, and institutional compliance inspection. The new law states t...

Medical physiology laboratories, traditionally devoted to animal experimentation, face unprecedented difficulties linked to cost, staffing, instrumentation, and the use of animals. At the same time, laboratory experiences with living creatures play a unique role in medical education. In this article we describe the use of venipuncture and subsequent blood analysis, with medical students serving...