The immediate haemodynamic dose response effects of beta blockade (propranolol: 2 to 16 mg) were compared with those of combined alpha beta blockade (labetalol: 10 to 80 mg) in a randomised study of 20 patients with stable angina pectoris. After control measurements, the circulatory changes induced by four logarithmically cumulative intravenous boluses of each drug in equivalent beta blocking d...

The effect of a single oral dose of $-blocker (Metoprolol) versus combined a and R-blocker (Labetalol) was evaluated in two groups of patients; control (C) normotensive and hypertensive (H) group with mild to moderate elevation of blood pressure. Each group consisted of ten subjects. The study comprises monitoring the heart rate (HR) and blood pressure (BP) response IO two tests; hand grip test...

The hemodynamic effects of labetalol and sodium nitroprusside were compared in 19 subjects who became hypertensive at the conclusion of elective carotid endarterectomy. Following randomization and standard anesthetic protocol, treatment was administered when blood pressure exceeded 160 mmHg systolic or 90 mmHg diastolic at the conclusion of surgery. Group 1 subjects (n = 9) received 0.25 mg/kg ...

Acute blood pressure elevations are commonly treated in hospitalized patients. There are no guidelines for appropriate practice and no evidence that such treatment is useful. The authors performed a retrospective review of medical and pharmacy records to determine how often intravenous hydralazine and labetalol are ordered and administered. During a 1-year study period, a total of 29,545 hospit...

Twenty-four-hour ambulatory blood pressure, including the acceleration phase, and left ventricular mass were evaluated in 16 patients with isolated systolic hypertension (standing blood pressure greater than or equal to 160 mm Hg systolic and less than or equal to 95 mm Hg diastolic). After a 4-week, single-blind, placebo period, each patient underwent 24-hour ambulatory blood pressure monitori...

In a country like India, where maternal mortality rate is still very high despite progress and development which has consistently been made in the health services, big proportion deprived of it. Hypertension most common medical problem encountered during pregnancy. This study was undertaken to compare efficacy labetalol versus methyldopa treatment pre-eclampsia prevention further complications....

BACKGROUND Rhinoplasty is one of the most common surgeries of the plastic surgery and as well as ear, throat and nose. Intra-operative bleeding during surgery is one of the most important factors that may impair the surgeon’s job. Providing a clean blood-free surgical filed makes the operation faster, easier and with a better quality. One way to achieve this goal is to induce hypotension. This...

The effects on portal pressure of the vasodilatory drugs isosorbide dinitrate and verapamil and of an alpha and beta blocking agent, labetalol, were assessed in 21 patients with cirrhosis and portal hypertension. The wedged hepatic venous pressure gradient (wedged minus free hepatic venous pressures) was used as an index of portal pressure and was not significantly changed by treatment with lab...

Labetalol, an antihypertensive agent that blocks both beta- and alpha-adrenergic receptors, was administered intravenously to 19 patients with accelerated hypertension who required rapid lowering of blood pressure. Systolic blood pressure was lowered from 209 +/- 4 to 143 +/- 2 mm Hg; diastolic blood pressure was reduced from 140 +/- 2 to 93 +/- 2 mm Hg. Side-effects were minimal and included n...