The effects of supplemental histidine on the anaemia of 16 chronically uraemic patients and 26 patients undergoing maintenance dialysis were assessed. Patients were given either L-histidine 4 g/day or placebo for a mean of 17-5 weeks in a randomized double-blind controlled study. Haemoglobin and packed cell volume increased slightly and to a similar degree in the patients on dialysis receiving ...

Histamine is an important chemical mediator for a wide variety of physiological reactions. L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. In this study, we determined the crystal structure of human HDC (hHDC) complexed with the inhibitor histidine methyl ester. This structure shows the detai...

Using a double-lumen tube jejunal perfusion system in vivo, the mutual effects of carnosine (beta-alanyl-L-histidine) and glycylglycine on their respective absorption rates have been studied in six Zambian African adults. Data on the effect of the constituent amino-acids of carnosine on glycylglycine absorption rate have similarly been obtained. The solutions infused in each subject contained (...

MtATP-phosphoribosyltransferase (MtATP-PRT) is an enzyme catalyzing the first step of the biosynthesis of L-histidine in Mycobacterium tuberculosis, and proposed to be regulated via an allosteric mechanism. Native mass spectrometry (MS) reveals MtATP-PRT to exist as a hexamer. Conformational changes induced by L-histidine binding and the influence of buffer pH are determined with ion mobility M...

I N Neurospora, L-histidinol is the immediate precursor of L-histidine, as shown by the isolation of L-histidinol dehydrogenase and the study of its catalytic functions (AMES 1957; CREASER, BENNETT and DRYSDALE 1965). The failure of histidine mutants, with the histidinol dehydrogenase function intact, to grow on histidinol, suggests that histidinol cannot enter the cell. However, CATCHESIDE ( 1...

Data presented in this report point to carbon at.om 2 of L-histidine as an important source of the carbon of labile methyl groups. The results obtained in direct studies of the isolated perfused normal and cirrhotic rat liver are qualitatively and quantitatively similar t,o those obtained with intact normal rats and rats kept on a choline-deficient diet (1) for a short time (10 days) and a long...

ABSTRACT. A new three metal complexes of La(III), Ce(IV) and UO2(II) ions have been synthesized based on a Schiff base derived from the condensation L-histidine anisaldehyde. All prepared compounds were characterized by different spectroscopic techniques Density-functional theory (DFT) calculations. The proposed to an octahedral structure investigated results. optimized shape, numbering system,...

Beneficial microbes and probiotic species, such as Lactobacillus reuteri, produce biologically active compounds that can modulate host mucosal immunity. Previously, immunomodulatory factors secreted by L. reuteri ATCC PTA 6475 were unknown. A combined metabolomics and bacterial genetics strategy was utilized to identify small compound(s) produced by L. reuteri that were TNF-inhibitory. Hydrophi...

The essentiality of histidine in healthy adults is a controversial topic. To study the potential metabolic effects of a lack of exogenous histidine, four healthy adults consumed a histidine-free diet, with adequate energy and 1.0 g/(kg d) of an L-amino acid mixture for 48 d. Protein metabolism was monitored every 4 d by using indicator amino acid (L-[1-C]phenylalanine) oxidation (in four subjec...