lysozyme is a bactericidal enzyme whose structure and functions change in diabetes. chemical chaperones are small molecules including polyamines (e.g. spermine), amino acids (e.g. l-lysine) and polyols (e.g. glycerol). they can improve protein conformation in several stressful conditions such as glycation. in this study, the authors aimed to observe the effect of l-lysine as a chemical chaperon...

Hantaviruses are important emerging pathogens belonging to the Bunyaviridae family. Like other segmented negative strand RNA viruses, the RNA-dependent RNA polymerase (RdRp) also known as L protein of hantaviruses lacks an intrinsic "capping activity". Hantaviruses therefore employ a "cap snatching" strategy acquiring short 5' RNA sequences bearing 5'cap structures by endonucleolytic cleavage f...

We describe two new Eulerian Rankin-Selberg integrals, using the same Eisenstein series defined on the group E8, and cuspidal representations from GL5 and GSpin11, respectively. Connections with past work of Ginzburg, Bump-Ginzburg, Jiang-Rallis and others are described. We give some details of how to relate our two integrals via formal manipulations. It is a fact of classical invariant theory ...

The Nadaraya-Watson estimator of regression is known to be highly sensitive to the presence of outliers in the sample. A possible way of robusti-fication consists in using local L-estimates of regression. Whereas the local L-estimation is traditionally done using an empirical conditional distribution function, we propose to use instead a smoothed conditional distribution function. We show that ...

BACKGROUND One hallmark of uremia is the impairment of neuro-cognitive function. Anecdotal clinical description from the early days of chronic dialysis therapy impressively illustrates the improvement of those functions by chronic hemodialysis treatment. Fortunately, today, uremia is only rarely observed in industrialized countries as many patients seek medical/nephrological attention prior to ...

Let CA/Q be the curve y = x + A, and let L(s, JA) denote the L-series of its Jacobian. Under the assumption that the sign in the functional equation for L(s, JA) is +1, we evaluate the critical value L(1, JA) in terms of the value of a theta series for Q( √ 5) depending on A at a CM point coming from Q(ζ5).