On the pharmaceutical account of the reported anticancer activity of thieno[2,3-b] pyridine and condensed thieno[2,3-b] pyridine, new compounds containing thieno[2,3-b] pyridine condensed with each of pyridine, cyclopentyl, tetrahydroquinoline, pyrimidine, 1,6-naphthiridin, benzofuro[2,3-b] pyridine, imidazo[1,2-c] pyrimidine, [1,2,3] triazolo[1,5-a] pyrimidine were synthesized through differen...

A series of supramolecular assemblies of the type [Ru(L-L)2(L'-L)MX2)](n+) are reported where L-L is 2,2'-bipyridine (bipy), 4,4'-di-tetra-butyl-bipyridine (tbbipy) or 4,4'-diethoxycarbonyl-2,2'-bipyridine (dceb), L-L' is tetrapyrido[3,2-a:2',3'-c:3'',2''-h:2''',3'''-j]phenazine (tpphz), 2,2':5',2''-terpyridine (2,5-bpp), 2,2':6',2''-terpyridine, (2,6-bpp), 2,5-di(pyridine-2-yl)pyrazine (2,5-dp...

In the title coordination polymer, [HgCl(2)(C(11)H(9)N(3))](n), the Hg(II) ion is coordinated by three N atoms from two N-[(E)-pyridin-2-yl-methyl-idene]pyridin-3-amine (L) ligands and two chloride anions in a distorted trigonal-bipyramidal geometry. The two pyridine rings in L form a dihedral angle of 50.0 (2)°. L ligands bridge adjacent HgCl(2) units into polymeric chains propagating in [010]...

Endothelial cell membranes, the site of the blood-brain barrier, were obtained from the capillaries of cow brain. The luminal and abluminal membranes were separated by centrifugation on a discontinuous Ficoll gradient. Electron microscopy revealed that the membrane preparations consisted almost entirely of sealed vesicles. The release of latent enzyme activity showed that both membrane preparat...

Reaction of [RuVI(N)(L1)(MeOH)]+ (L1 ) N,N′-bis(salicylidene)-o-cyclohexylenediamine dianion) with excess pyridine in CH3CN produces [Ru(L)(py)2] and N2. The proposed mechanism involves initial equilibrium formation of [RuVI(N)(L1)(py)]+, which undergoes rapid N · · · N coupling to produce [(py)(L1)RuIIINtN-RuIII(L1)(py)]2+; this is followed by pyridine substituion to give the final product. Th...

The idea that the environmental toxin beta-N-methylamino-l-alanine (BMAA) is involved in neurodegenerative diseases on Guam has risen and fallen over the years. The theory has gained greater interest with recent reports that BMAA is biomagnified, is widely distributed around the planet, and is present in the brains of Alzheimer's patients in Canada. We provide two important new findings. First,...

We have investigated the electrochemical, spectroscopic and electroluminescent properties of a family of aza-aromatic complexes of ruthenium of type [Ru(bpy/phen)2(L)] 2+ (4d) with three isomeric L ligands, where, bpy 1⁄4 2,20-bipyridine, phen 1⁄4 1,10-phenanthroline and the L ligands are 3-(2-pyridyl) [1,2,4]triazolo[1,5-a]pyridine (L), 3-(2-pyridyl[1,2,3])triazolo[1,5-a]pyridine (L) and 2-(2-...