نتایج جستجو برای: klf4

تعداد نتایج: 1595  

Journal: :Circulation research 2008
Tadashi Yoshida Klaus H Kaestner Gary K Owens

Phenotypic switching of smooth muscle cells (SMCs) plays a key role in vascular proliferative diseases. We previously showed that Krüppel-like factor 4 (Klf4) suppressed SMC differentiation markers in cultured SMCs. Here, we derive mice deficient for Klf4 by conditional gene ablation and analyze their vascular phenotype following carotid injury. Klf4 expression was rapidly induced in SMCs of co...

Journal: :Development 2002
Jonathan P Katz Nathalie Perreault Bree G Goldstein Catherine S Lee Patricia A Labosky Vincent W Yang Klaus H Kaestner

Klf4 (formerly GKLF) is a zinc-finger transcription factor expressed in the epithelia of the skin, lungs, gastrointestinal tract and several other organs. In vitro studies have suggested that Klf4 plays an important role in cell proliferation and/or differentiation. Mice homozygous for a null mutation in Klf4 die within 15 hours of birth and show selective perturbation of late-stage differentia...

Journal: :Molecular cancer research : MCR 2008
Amr M Ghaleb Gaurav Aggarwal Agnieszka B Bialkowska Mandayam O Nandan Vincent W Yang

The zinc finger-containing transcription factor, Krüppel-like factor 4 (KLF4), inhibits cell proliferation. An in vivo tumor-suppressive role for KLF4 is shown by the recent finding that Klf4 haploinsufficiency in Apc(Min/+) mice promotes intestinal tumorigenesis. Studies also show that KLF4 is required for the terminal differentiation of goblet cells in the mouse intestine. The Notch signaling...

2008
Daoyan Wei Masahsi Kanai Zhiliang Jia Xiangdong Le Keping Xie

The zinc finger transcription factor Krüppel-like factor 4 (KLF4) has been implicated in both tumor suppression and progression. However, its function in pancreatic cancer has not been well characterized. Here, we show that pancreatic cancer cell lines expressed various levels of KLF4 RNA and protein. Ectopic expression of KLF4 by FG and BxPC-3 pancreatic cancer cells resulted in cell cycle arr...

2014
Wen-Ting Yang Peng-Sheng Zheng

OBJECTIVE The KLF4 gene has been shown to be inactivated in cervical carcinogenesis as a tumor suppressor. However, the mechanism of KLF4 silencing in cervical carcinomas has not yet been identified. DNA methylation plays a key role in stable suppression of gene expression. METHODS The methylation status of the KLF4 promoter CpG islands was analyzed by bisulfite sequencing (BSQ) in tissues of...

Journal: :American journal of physiology. Heart and circulatory physiology 2009
Rebecca A Deaton Qiong Gan Gary K Owens

There is clear evidence that the phenotypic modulation of smooth muscle cells (SMCs) contributes to the pathophysiology of vascular disease. Phenotypic modulation refers to the unique ability of SMCs to alter their phenotype in response to extracellular stimuli and is hallmarked by the loss of SMC marker gene expression. The transcription factor Krüppel-like factor 4 (KLF4) is a known powerful ...

2010
Ji Wang Robert F. Place Vera Huang Xiaoling Wang Emily J. Noonan Clara E. Magyar Long-Cheng Li

KLF4/GLKF4 is a transcription factor that can have divergent functions in different malignancies. The role of KLF4 in prostate cancer etiology remains unclear. We have recently reported that small double-stranded RNA can induce gene expression by targeting promoter sequence in a phenomenon referred to as RNA activation (RNAa). In this study, we examine KLF4 levels in prostate cancer tissue and ...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2012
Xin-hua Zhang Bin Zheng Chun Gu Jian-ran Fu Jin-kun Wen

OBJECTIVE Cardiovascular effects of angiotensin II are primarily mediated via the angiotensin II type 1 receptor (AT1R). Krüppel-like factor 4 (KLF4), a transcription factor that binds to the transforming growth factor (TGF)-β control element (TCE), regulates a variety of receptor expression in vascular smooth muscle cells. In the present study, we investigated the mechanisms of TGF-β-mediated ...

Journal: :Cancer research 2005
Daoyan Wei Weida Gong Masashi Kanai Christian Schlunk Liwei Wang James C Yao Tsung-Teh Wu Suyun Huang Keping Xie

Krüppel-like factor 4 (KLF4) is highly expressed in epithelial tissues such as the gut and skin. However, the role of KLF4 in human gastric cancer development and progression is unknown. Here we show that KLF4 protein expression was decreased or lost in primary tumors and, in particular, lymph node metastases when compared with that in normal gastric mucosa. Moreover, loss of KLF4 expression in...

Journal: :Blood 2007
Michael G Kharas Isharat Yusuf Vanessa M Scarfone Vincent W Yang Julia A Segre Claudia S Huettner David A Fruman

Genes that are strongly repressed after B-cell activation are candidates for being inactivated, mutated, or repressed in B-cell malignancies. Krüppel-like factor 4 (Klf4), a gene down-regulated in activated murine B cells, is expressed at low levels in several types of human B-cell lineage lymphomas and leukemias. The human KLF4 gene has been identified as a tumor suppressor gene in colon and g...

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