BACKGROUND Pulmonary alveolar proteinosis (PAP) is a rare disorder characterised by abundant alveolar accumulation of surfactant lipoproteins. Serum levels of KL-6, high molecular weight human MUC1 mucin, are increased in the majority of patients with PAP. The prognostic significance of KL-6 in PAP is still unknown. Aim of the study was to evaluate whether serum KL-6 levels correlate with the o...

STUDY OBJECTIVES Serum KL-6 (Krebs von den Lungen-6) has been recognized to be a marker for the activity of diffuse interstitial lung diseases. The purpose of the study is to evaluate serum KL-6 measurement as a marker for farmer's lung disease (FLD). DESIGN A cross-sectional survey of a cohort of dairy farmers. Retrospective measurement of KL-6 stored serum samples from those dairy farmers p...

We analyze KL lepton pair decays of KL → l+l−γ and KL → l+l−l′+l′− (l, l = e, μ) within the framework of the light-front QCD approach (LFQA). With the KL → γγ form factors evaluated in a model with the LFQA, we calculate the decay branching ratios and find out that our results are all consistent with the experimental data. In addition, we study KL → l+l− decays. We point out that our prediction...

The heterochromatic Y chromosome of Drosophila melanogaster contains approximately 40 Mb of DNA but has only six loci mutable to male sterility. Region h1-h9 on YL, which carries the kl-3 and kl-5 loci, induces male sterility when present in three copies. We show that three separate segments within the region are responsible for the triplosterility and have an additive effect on male fertility....

BACKGROUND Diffuse alveolar hemorrhage syndrome is a life threatening condition with diverse etiologies. Sensitive prognostic markers for diffuse alveolar hemorrhage have not been well investigated. Serum KL-6 is a biomarker for various interstitial lung disease associated with disease activity and prognosis. The purpose of the present study was to evaluate the clinical utility of serum KL-6 le...

The Kit ligand (KL)/Kit receptor pair functions in hematopoiesis, gametogenesis, and melanogenesis. KL is encoded at the murine steel (Sl) locus and encodes a membrane growth factor which may be proteolytically processed to produce soluble KL. The membrane-associated form of KL is critical in mediating Kit function in vivo. Evidence for a role of cytoplasmic domain sequences of KL comes from th...

A consistent census of penguins in the ∆I = 1/2 rule is taken from the η0 pole contribution to the radiative KL → γγ, KS → π0γγ and K+ → π+γγ decay modes. We briefly comment on its impact for KL → π0π0γγ, KL → π+π−γ and check its compatibility with the KL−KS mass difference and the CP violating ε′/ε parameter.

The growing data demonstrate that Klotho (KL) is deeply implicated in the diabetic nephropathy. The circulating form of α-Klotho (α-KL) named as soluble KL functions as an endocrine substance that exerts heterogeneous actions including the modulation of renal function upon hyperglycemia, regulation of cell compensation, downgrade inflammation and anti-oxidation. There is a positive correlation ...

KL-6 is a glycoprotein found predominantly on type II pneumocytes and alveolar macrophages, and often shows increased serum levels in patients with interstitial pneumonia. We report a case of mycobacterium avium complex (MAC) infection whose disease activity was correlated with KL-6 levels in serum. During treatment of rheumatoid arthritis (RA)-associated interstitial lung disease (ILD) with pr...