Gluconeogenesis from lactate in isolated hepatocytes is activated by a variety of hormonal stimuli. As to the mechanism(s) of action, it is widely accepted that the effect of glucagon is mediated by cyclic AMP (Exton et al., 1970, 1971), and adrenaline and phenylephrine have been shown to activate gluconeogenesis without involvement of cyclic AMP (Tolbert et al., 1973; Tolbert & Fain, 1974; Kne...
