HE literature on the genetic and antigenic basis of tumor transplantation has T been reviewed by BITTNER (1935), LITTLE (1941; 1947), HAUSCHKA, (1952) and SNELL (1953b, c). In mice, the genetic loci involved were named “histocompatibility” loci by SNELL (1948), the prefix “histo” being used to denote the probable similarity of genes determining reactions to neoplastic and normal tissue transpla...

Techniques known as Nonlinear Set Membership prediction, Lipschitz Interpolation or KinkyInference are approaches to machine learning that utilise presupposed Lipschitz properties tocompute inferences over unobserved function values. Provided a bound on the true best Lipschitzconstant of the target function is known a priori they offer convergence guarantees as well asbounds aro...

By 1807 the scale of the task the Huddersfield Canal Company had taken on must have been painfully evident. The canal involved the construction of the longest man-made tunnel of the time, but this was only one of the problems faced by the canal company as costs spiralled and a mixture of poor workmanship and the harsh conditions of the Pennine moorlands created additional delays. Construction h...

introduction: chlorpyrifos (cpf), an organophosphate insecticide, was evaluated for potential teratogenic effects in mice. a single oral dose of insecticide (i.e. 72, 36 18 or 9 mg/kg) was given to the pregnant females on gestation day6 (gd6). these doses correspond 50, 25, 12.5 and 6.25% to the calculated ld50 value (144 mg/kg) for the pregnant mice. no signs of overt toxicity were observed at...

We consider a model of static cosmic string loops in type IIB string theory, where the strings wrap cycles within the internal space. The strings are not topologically stabilised, however the presence of a lifting potential traps the windings giving rise to kinky cycloops. We find that PBH formation occurs at early times in a small window, whilst at late times we observe the formation of dark m...

Introduction: Chlorpyrifos (CPF), an organophosphate insecticide, was evaluated for potential teratogenic effects in mice. A single oral dose of insecticide (i.e. 72, 36 18 or 9 mg/kg) was given to the pregnant females on gestation day6 (GD6). These doses correspond 50, 25, 12.5 and 6.25% to the calculated LD50 value (144 mg/kg) for the pregnant mice. No signs of overt toxicity were observed at...

Menkes kinky-hair disease (trichopoliodystrophy, steelyhair disease) is an X-linked neurodegenerative disorder that occurs predominantly in males. It was first described by Menkes in 1962 [1]. The characteristic clinical features are steely hair, profound retardation, spastic quadriparesis, seizures, and hypothermia. The disease is caused by an underlying defect of copper metabolism; and the se...

A 10-month-old female presented with severe progressive wedge-shaped thickening and discoloration of all twenty nails. Further evaluations revealed palmoplantar keratoderma along with recurrent acral blisters causing residual crusted ulcers which were present during the past six months. Other findings included scalp kinky hair and dental caries. Past medical and family history had remarkable fi...