The cell cycle stimulation of individual species of the uracil DNA glycosylase was examined in WI-38 normal diploid fibroblasts. The nuclear uracil DNA glycosylase was induced as WI-38 cells traversed the cell cycle. In contrast, the specific activity of the mitochondrial glycosylase remained constant during cell proliferation. The two enzyme activities can be further distinguished by their elu...

Kinetic investigations of stimulus response coupling in the green alga Chara have revealed that an intermediate second messenger is formed in the process of membrane excitation. This second messenger links electrical stimulation to the mobilization of Ca from internal stores. In the present work, the experimentally based kinetic model, which describes the stimulus-dependent production of the se...

The sense of equilibrium aggregates several interacting cues. On patients with vestibular loss, vision plays a major role. In this study, the goal is to propose a new immersive therapy based on 3D optokinetic stimulation. We propose to demonstrate that 3D monoscopic optical flows is an efficient tool to stimulate adaptive postural adjustment. We developed an immersive therapeutic platform that ...

The personal risks of infection, as well the conditions for achieving herd immunity, are strongly dependent on an individual’s response to infective agents one hand, and reactions vaccination other hand. main goal this work is illustrate importance quantitative individual effects disease risk in a simple way. applied model was able effects, cases different reactions, after exposition viruses or...

A number of cell types have previously been shown to bind tissue plasminogen activator (tPA), which in some cases can remain active on the cell surface resulting in enhanced plasminogen activation kinetics. We have investigated several cultured cell lines, U937, THP1, K562, Molt4, and Nalm6 and shown that they bind both tPA and plasminogen and are able to act as promoters of plasminogen activat...

Brown adipose tissue (BAT) thermogenesis is an emerging target for prevention and treatment of obesity. Mitochondria are the heat generators of BAT. Yet, there is no noninvasive means to image the temporal dynamics of the mitochondrial activity in BAT in vivo. Here, we report a technology for quantitative monitoring of principal kinetic components of BAT adaptive thermogenesis in the living ani...

biophysical profile (bpp) test is the most commonly used antenatal test of fetal well-being. purpose of this study is determining the influence of acoustic stimulation (as) on bpp testing time. about 55 pregnant women at 35 to 42 weeks who referred to department of obstetric & gynecology at university of medical sciences, tabriz, iran, were selected randomly. we used abdominal ultrasound guidan...

background: the purpose of this study was to investigate the ratio of electromyography (em g) activities of the vastus medialis obliqus (vmo) and vastus lateralis (vl) within seven angles of knee joint range of motion using isometric contraction in open kinetic chain (ok c) and closed kinetic chain (ckc). methods: the dominant knees of 44 healthy female subjects (mean age: 24.84 with range: 20-...

A novel model consisting of basic micro-processes has been developed on the basis of the classic diffusion theory. It is first time that the concept of exchange rate has been introduced and the growing process of surfactant-mediated epitaxial thin-film growth has been simulated with Kinetic Monte Carlo (KMC) technique. The results of simulation found that the exchange reaction of RLA model is a...