نتایج جستجو برای: kindling

تعداد نتایج: 1131  

2014
Nasibe Akbari Mahmoud Elahdadi Salmani Mahdi Goudarzvand Taghi LashkarBoluki Iran Goudarzi Kataneh Abrari

INTRODUCTION Epilepsy is a neural disorder in which abnormal plastic changes during short and long term periods lead to increased excitability of brain tissue. Kindling is an animal model of epileptogenesis which results in changes of synaptic plasticity due to repetitive electrical or chemical sub-convulsive stimulations of the brain. Lateral hypothalamus, as the main niche of orexin neurons w...

Journal: :Journal of Neural Transplantation & Plasticity 1992
Qing Wu Toru Itakura Mitsukazu Nakai Kunio Nakai Norihiko Komai

Recent studies demonstrated that central norepinephrine (NE) plays an important suppressing role in the development of seizure in several experimental epileptic models. Transplantation of fetal NE-rich neurons in the locus ceruleus into either hippocampus or amygdalapiriform cortex can retard the development of seizures in hippocampal kindling. The present study was designed to investigate the ...

2013
Khadijeh Esmaeilpour Yaser Masoumi-Ardakani Vahid Sheibani Amir Shojaei Shaahin Harandi Javad Mirnajafi-Zadeh

Low frequency stimulation (LFS) is a potential alternative therapy for epilepsy. However, it seems that the anticonvulsant effects of LFS depend on its target sites in the brain. Thus, the present study was designed to compare the anticonvulsant effects of LFS administered to amygdala, piriform cortex and substantia nigra on amygdala kindling acquisition. In control group, rats were kindled in ...

2014
FEI YE XU-QIN CHEN GUAN-SHUI BAO YIN HUA ZHE-DONG WANG YI-CHUAN BAO

The objective of this study was to analyze the changes in expression and the possible functions of interleukin-6 (IL-6) in electrical kindling of the basolateral amygdala (BLA) in epileptic rats. Bipolar electrodes were implanted into the BLA of Sprague-Dawley rats, and the rats were then subjected to chronic electrical stimulation through the electrodes to induce kindling. The seizure characte...

Journal: :Epilepsia 1998
I M Germano E F Sperber S Ahuja S L Moshé

PURPOSE Neuronal migration disorders (NMD) are often found in patients with epilepsy. However, the mechanisms linking these two pathologies are not yet fully understood. In this study, we evaluated whether NMD increased kindling seizure susceptibility and seizure-induced acute neuronal damage in the immature brain. METHODS Experimental NMD were produced by exposing pregnant rats (gestation da...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1995
T Sutula S Lauersdorf M Lynch C Jurgella A Woodard

Repeated activation of neural pathways by kindling induces brief seizures, permanent increases in seizure susceptibility, neuronal loss in the hippocampus, and mossy fiber sprouting in the dentate gyrus. Because kindling induces permanent cellular alterations in hippocampal pathways that have been implicated in memory, it was of interest to determine if kindling also induces long-lasting impair...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 1996
T Sutula J Koch G Golarai Y Watanabe J O McNamara

The NMDA receptor plays an important role in patterning neural connectivity in the developing brain. In the adult brain, repeated kindling stimulation of limbic pathways increases the NMDA-dependent component of synaptic transmission in granule cells of the dentate gyrus (DG) and also induces sprouting of the mossy fiber axons of granule cells that reorganizes synaptic connections in the DG. Be...

Journal: :Cerebral cortex 2004
Pamela A Valentine G Campbell Teskey Jos J Eggermont

The effect of electrical kindling, applied twice daily in primary auditory cortex on the neural response properties and tonotopic organization in the lightly ketamine anesthetized cat is presented. Kindling refers to a highly persistent modification of brain functioning in response to repeated application of initially sub-convulsant electrical stimulation, typically in the limbic system but her...

2015
Fatemeh Etemadi Mohammad Sayyah Hamid Gholami Pourbadie Vahab Babapour

INTRODUCTION Although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (HK) develops very slowly. Hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. In this article we aimed at finding the optimal stimulus pattern, which yields the fastest HK rate. METHODS Stimulus patterns with different duration (2,...

Journal: :Neuroscience 1995
M Vreugdenhil W J Wadman

Daily tetanic stimulation of the Schaffer collaterals generates an epileptogenic focus in area CA1 of the rat hippocampus, ultimately leading to generalized tonic-clonic convulsions (kindling). Potassium currents were measured under voltage-clamp conditions in pyramidal neurons, acutely dissociated from the focus of fully kindled rats, one day and six weeks after the last generalized seizure. T...

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