Bone and soft tissue tumours are seen infrequently in district general hospitals and diagnosis requires a good history and examination with good recognition of red flag symptoms offered by the patient. Delay in diagnosis of these potentially life changing diagnoses have an effect on treatment options and the potential for curative therapy. In the UK, referral to specialist bone and soft tissue ...

Aetiology Smoking – increased RR x7 Analgaesic abuse Phenacetin most commonly described – increased RR 3.6x. Also associated with codeine, paracetamol and salyicylates Associated papillary necrosis on imaging associated with risk increase x7, which is synergistic with phenacetin abuse (20x) Characteristic finding of thickened basement membrane on histology – should alert physician to need for c...

We present an example here of pathologically documented and coexistent double malignant tumours of the colon and kidney. In the case reported, an adenocarcinoma of the caecum-colon was detect first whilst the renal tumour was discovered by chance during staging prior to surgery. Both tumours were asymptomatic and the characteristics of the renal mass (suggestive for primary tumour) excluded the...

BACKGROUND Carcinoid tumours are neuroendocrine neoplasms mainly located in the gastrointestinal tract and bronchopulmonary system. Our study's aim was to characterise the familial nature of gastrointestinal carcinoid tumours using the Swedish Family-Cancer Database, which includes >11.5 million individuals. METHODS Familial relative risks (RRs) of carcinoid tumours were estimated for individ...

background petro-clival, clival and spheno-petro-clival tumours are still a neurosurgical challenge. usually, the classical skull base transpetrous approaches are employed, although they are burdened by an important rate of morbidity, and a very low rate of radical removal is reported. conclusions anterior transoral and transsphenoidal approaches are indicated for clival and spheno-petro-clival...

The utility of cancer cell lines is affected by the similarity to endogenous tumour cells. Here we compare genomic data from 65 kidney-derived cell lines from the Cancer Cell Line Encyclopedia and the COSMIC Cell Lines Project to three renal cancer subtypes from The Cancer Genome Atlas: clear cell renal cell carcinoma (ccRCC, also known as kidney renal clear cell carcinoma), papillary (pRCC, al...

Small renal masses (SRMs) are currently defined as kidney lesions measuring ≤4cm in diameter. The overall incidence of renal masses has risen steadily, reaching a plateau only in recent years, and the steepest rise has been demonstrated among SRMs. The current incidence is approximately 10.8 per 100,000 in the United States, with localized stage I disease representing >50% of all newly diagnose...

PURPOSE To examine patients with vertebral tumour metastasis using transpedicular biopsy for diagnosing unknown primary tumours. METHODS 13 men and 8 women aged 41 to 80 (mean, 61) years with vertebral tumour metastasis of unknown primary origin underwent transpedicular biopsy of the affected vertebra. RESULTS The origins of the primary tumours were lung cancer (n = 6), prostate cancer (n =...