CONTEXT Vitamin D3 might benefit prostate cancer (PCa) patients because prostate cells can locally synthesize the active hormone calcitriol. OBJECTIVE Our objective was to determine the effects of oral vitamin D3 on vitamin D metabolites and PCa proliferative activity in prostate tissue. DESIGN AND SETTING We conducted a double-blind randomized clinical trial at surgical oncology clinics in...

One hundred and four surgically resected lung tumours were labelled in either cryostat or freeze dried sections with a monoclonal antibody (Ki67), which reacts with a nuclear antigen expressed by proliferating cells. The tumours were categorised semiquantitatively into four proliferative grades, a classification that can be performed rapidly and reproducibly by the pathologist. In keeping with ...

The human microbiome has a fundamental role in skin homeostasis, barrier function and host immune networks. Acute chronic conditions are often associated with imbalances host-microbiome-immune interactions. Despite recent advances research, there limited models for studying these interactions healthy diseased skin, therefore we have developed model to investigate how different profiles alter ep...

Objective Meningioma recurrence after resection is likely influenced by multiple surgical and histologic factors. In this study, the degree of resection and tumor immunoreactivity to MIB-1 (i.e., Ki-67 labeling index (LI)) are described in recurrent and non-recurrent meningioma cases. Methods Data regarding tumor location, the degree of resection, histologic features, and the degree of Ki-67 po...

The first phase IIb safety and efficacy trial of a new tuberculosis vaccine since that for BCG was completed in October 2012. BCG-vaccinated South African infants were randomized to receive modified vaccinia virus Ankara, expressing the Mycobacterium tuberculosis antigen 85A (MVA85A), or placebo. MVA85A did not significantly boost the protective effect of BCG. Cryopreserved samples provide a un...

Myopericytoma (MPC) of the oral cavity is extremely rare. Herein reported is a case of MPC of low grade malignancy in the oral cavity. A 61-year-old man noticed a tumor of the cheek mucosa, and admitted to our hospital. Oral examination revealed a reddish elevated tumor of the cheek mucosa. Tumorectomy with wide margins was performed. The clinical diagnosis was pyogenic granuloma. Grossly, the ...

BACKGROUND It has been suggested that the proliferative capacity of cells from individuals with HIV or both HIV and helminth infections is attenuated and cytokine production is dysregulated. This study describes peripheral blood mononuclear cell proliferation capacity and cytokine profile from individuals with HIV or both HIV and helminth infections in South Africa. METHODS Forty HIV-infected...