Methamphetamine is a highly addictive psychostimulant drug of abuse that causes neurotoxicity with high or repeated dosing. Earlier studies demonstrated the ability of the selective σ receptor ligand N-phenethylpiperidine oxalate (AC927) to attenuate the neurotoxic effects of methamphetamine in vivo. However, the precise mechanisms through which AC927 conveys its protective effects remain to be...

BACKGROUND The C-terminal domain of the heavy chain of tetanus toxin (Hc-TeTx) is a nontoxic peptide with demonstrated in vitro and in vivo neuroprotective effects against striatal dopaminergic damage induced by 1-methyl-4-phenylpyridinium and 6-hydoxydopamine, suggesting its possible therapeutic potential in Parkinson's disease. Methamphetamine, a widely abused psychostimulant, has selective d...

There are a several drugs that lead to the production of methamphetamine and/or amphetamine in the body which are subsequently excreted in the urine. These drugs raise obvious concerns when interpreting positive amphetamine drug testing results. Famprofazone is an analgesic found in a multi-ingredient medication (Gewodin) used for pain relief. Two Gewodin tablets (50 mg of famprofazone) were ad...

It is well known that some XML elements correspond to objects (in the sense of object-orientation) and others do not. The question we consider in this paper is what benefits we can derive from paying attention to such object semantics, particularly for the problem of keyword queries. Keyword queries against XML data have been studied extensively in recent years, with several lowest-common-ances...

Dear Editor, Methamphetamine is a potent neurotoxin which can cause dopaminergic degeneration.1 In emergency department settings of hospitals, common presenting symptoms relating to Methamphetamine intoxication include chest pain, hypertension, shortness of breath, and tachycardia.2 In Iran, Methamphetamine intoxication has recently emerged as a crucial health problem in clinical and therapeuti...

OBJECTIVES To determine the prevalence and factors of Viagra use in combination with crystal methamphetamine and its association with HIV risk behavior in a probability sample of men who have sex with men (MSM). STUDY DESIGN A cross-sectional, random-digit dial telephone survey of MSM in San Francisco conducted between June 2002 and January 2003. RESULTS Of the 1976 MSM, 13.5% used Viagra a...

Methamphetamine and related amphetamine compounds are among the most commonly used illicit drugs, with over 35 million users worldwide. In the United States, admissions for methamphetamine treatment have increased dramatically over the past 10 years. Methamphetamine use is prevalent among persons with HIV infection and persons at risk for HIV, particularly among men who have sex with men. In ad...

a b s t r a c t abstract- methamphetamine has rapidly become more prominent in iran, which is now second most common drug behind heroin. moreover, initiation of methamphetamine abuse is a major cause of failure of opioid treatment programs such as methadone maintenance treatment. this calls for development of more effective treatment methods for methamphetamine addiction, and especially develop...