conclusions our findings indicate that resistance of c. albicans strains to azoles is more common in tokat, turkey. therefore, a strategy to control the inappropriate and widespread use of antifungal drugs is urgently needed. fungal culturing and antifungal susceptibility testing will be useful in patient management as well as resistance surveillance. materials and methods a total of 201 c. alb...

methods the mice were divided into six groups including a normal control group, a placebo group, and three treatment groups receiving 50, 100, and 200 mg/kg doses of hydroalcoholic extract via intraperitoneal (ip) injection followed by inoculation with c. albicans. a control+ group, inoculated only with c. albicans, was also employed. after all treatments, the mice were killed by cervical decap...

The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. al...

BACKGROUND Photodynamic therapy (PDT) has been found to be effective in inhibiting biofilm producing organisms. We investigated the photodynamic effect of gold nanoparticle (GNP) conjugated photosensitizers against Candida albicans biofilm. We also examined the photodynamic efficacy of photosensitizer (PS) conjugated GNPs (GNP-PS) to treat skin and oral C. albicans infection in BALB/c mice. M...

The facultative anaerobic polymorphic fungus Candida albicans and the strictly anaerobic Gram-positive bacterium Clostridium difficile are two opportunistic pathogens residing in the human gut. While a few studies have focused on the prevalence of C. albicans in C. difficile-infected patients, the nature of the interactions between these two microbes has not been studied thus far. In the curren...

objective: the secreted aspartic proteinases (sap2) of candida albicans has prominent role on candida adherence, invasion, and pathogenicity. the aim of this study was cloning, expression and characterizing of sap2 enzyme. also in this study for the first time, the expression system p. pasturis was used for expressing the recombinant protein. materials and methods: c. albicans sap2 gene was am...

objective: approximately three-fourths of women experience an episode of vaginal candidiasis. candida albicans(c. albicans) is the etiological agent in over 80% of cases. c. albicans has numerous virulence factors such as the agglutinin-like sequence (als) genes which code the large glycoprotein family that has a role in the adherence of candida. the present study aims to evaluate expressions ...

The yeast Candida albicans is an oral commensal microorganism, occurring in the oral cavity of 50-70% of healthy individuals. Its effect on oral ecology has mostly been studied using dual-species models, which disregards the complex nature of oral biofilms. The aim of this study was to culture C. albicans in a complex model to study its effect on oral biofilms. Biofilms, inoculated using pooled...

Fungal infections of mucosal surfaces are extremely common, debilitating and often recurring diseases, which are frequently caused by the yeast Candida albicans. Furthermore, in the severely immunocompromised host, C. albicans may also cause deepseated or even life-threatening systemic infections. In order to colonize, infect and evade host defence mechanisms, C. albicans possesses a repertoire...

Background: Candida albicans is one of the most important opportunistic pathogens that suppress immunologic mechanisms of the host. It is speculated that structural and secretory proteins of C. albicans have immunomodulatory effects in cancer. Objective: To evaluate the effects of C. albicans structural and secreted proteins on intratumoral CD4/CD8 ratio as well as the survival rate in BALB/c t...