Ketorolac tromethamine injected intramuscularly (IM) has been shown to be an effective analgesic in treating patients with acute musculoskeletal pain in the emergency department (ED). The authors compare the efficacy of a single dose of IM ketorolac to osteopathic manipulative treatment (OMT) as delivered in the ED for the management of acute neck pain. A randomized clinical trial was conducted...

Background Ketorolac tromethamine is a nonsteroidal anti-inflammatory drug (NSAID) that extensively used for the management of renal colic in emergency department (ED). It has been proposed ketorolac at doses above its analgesic ceiling with no more advantages and increased risk adverse effects. In this study, we compared effects three intravenous patients colic. Methods This noninferiority, ra...

We investigated the mechanisms underlying the activation of endogenous opioids in placebo analgesia by using the model of human experimental ischemic arm pain. Different types of placebo analgesic responses were evoked by means of cognitive expectation cues, drug conditioning, or a combination of both. Drug conditioning was performed by means of either the opioid agonist morphine hydrochloride ...

During exercise, muscle mechanoreflex-mediated sympathoexcitation evokes renal vasoconstriction. Animal studies suggest that prostaglandins generated within the contracting muscle sensitize muscle mechanoreflexes. Thus we hypothesized that local prostaglandin blockade would attenuate renal vasoconstriction during ischemic muscle stretch. Eleven healthy subjects performed static handgrip before ...

Alcaftadine (ALC) and Ketorolac tromethamine (KET) binary combination is a new co-formulated pharmaceutical product that used to treat allergic conjunctivitis. The present work utilizes three simple, precise, accurate, rapid spectrophotometric chemometric methods determine the recently released formulation. include first derivative of absorbance spectrum (Method A), dual-wavelength B), subtract...

Aim: The development and optimization of Ketorolac tromethamine-loaded polylactic-co-glycolic acid nanoparticles (KT-NPs) for the treatment inflammatory processes eye. Materials & methods: KT-NPs were developed by factorial design characterized assessing their physicochemical properties. Biopharmaceutical behavior studies, ocular tolerance, anti-inflammatory efficacy bioavailability tests p...