Senecionine (SEN) is a representative of the hepatotoxic pyrrolizidine alkaloids. Although phase I metabolism for cytochrome P450-mediated metabolic activation of SEN was investigated extensively, phase II metabolism for glucuronidation of this compound has not been investigated until now. In our present study, one unique glucuronidation product of SEN in human liver microsomes (HLMs) was ident...

INTRODUCTION Subependymal nodule (SEN) and subependymal giant cell astrocytoma (SEGA) are brain lesions frequently found in tuberous sclerosis (TS). As about 10-15% of SENs enlarge and transform into SEGAs, we examined here the possible mechanism of the phenomenon. MATERIAL AND METHODS Using Western blot we studied 1 SEN and 3 SEGA samples; SEN and 1 SEGA came from the same TS patient. We eva...

Chronic respiratory disorders such as asthma are believed to be associated with adverse cardiovascular events. We hypothesize that asthmatic inflammation translates into systemic inflammation and alters vascular responses where adenosine (AD) plays an important role. Therefore, this study investigated the effects of aerosolized AD, used to elevate lung AD levels, on vascular reactivity and infl...

Penelitian ini bertujuaan untuk mengetahui faktor-faktor yang menyebabkan terjadinya pembiayaan bermasalah di KSPPS Salimah Kendal,untuk upaya penanganan terhadap anggota wanprestasi Kendal. Metode digunakan pada penelitian adalah metode lapangan, pendekatan kualitatif. Sumber data yaitu primer dan sekunder. manager,teller,karyawan bagian marketing Kendal.Sedangkan sumber sekunder buku dokument...

One of Amartya Sen’s most distinctive claims, and perhaps also one of his most controversial, is that there is an altruistic attitude toward others that does not make sense within the terms of rational choice theory, however broadly that theory is construed. He describes this attitude as one of “commitment” to others, contrasting itwith egoismandalsowith adistinct altruistic attitude he calls “...

The design and implementation of an interactive spot noise algorithm is presented. Spot noise is a technique which utilizes texture for the visualization of ow elds. Various design tradeoos are discussed that allow an optimal implementation on a range of high end graphical workstations. Two applications are given: the steering of a smog prediction simulation and browsing a very large data set r...

We deene a speciication language called`timed CRL'. This language is designed to describe communicating processes employing data and time. Timed CRL is the successor of CRL 17]. It diiers in two main aspects. It is possible to make explicit reference to time using a newàt' operator; p,t is the process p where the rst action must take place at time t. Furthermore, a distinction has been made bet...

The good parallel computing properties of sparse-grid solution techniques are investigated. For this, an existing sequential CFD code for a standard 3D problem from computational aerodynamics is restructured into a parallel application. The restructuring is organized according to a master/slave protocol. The coordinator modules developed thereby are implemented in the coordination language MANI...