Objective—To compare the reliability of quantitative measurement of minimum hip joint space with a qualitative global assessment of radiological features for estimating the prevalence of primary osteoarthritis (OA) of the hip in colon radiographs. Methods—All colon radiographs from patients aged 35 or older, taken at three diVerent radiographic departments in Iceland during the years 1990–96, w...

Osteoarthritis of the knee (OAK) is a common form of arthritis that can lead to substantial pain and disability. This commentary highlights key aspects of the recently published phase 3 A Efficacy and Safety Study of Two Doses of Intra-Articular Injection of Ampion™ in Adults With Pain Due to Osteoarthritis of the Knee (SPRING) study. SPRING (NCT01839331) was a multicenter, randomized, vehicle-...

BACKGROUND Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA). MATERIAL AND METHODS We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system. ...

BACKGROUND Gremlin-1, a bone morphogenetic protein (BMP) antagonist, is up-regulated in osteoarthritis (OA). Therefore, we aim to evaluate the correlation between gremlin-1 concentrations and the onset and severity of OA. MATERIAL AND METHODS We performed this cross-sectional study in a population of 212 patients with knee OA and 125 healthy controls. RESULTS Patients with knee OA had higher se...

Introduction The loss of glycosaminoglycans (GAGs) and breakdown of collagen are typical characteristics of early osteoarthritis (OA) (1). T1rho mapping has been shown to be sensitive to changes in cartilage proteoglycan loss (2). Previous studies have demonstrated that cartilage T1rho values are elevated in OA patients compared to corresponding healthy subjects (3, 4). Recent work has reported...

The paper describes the contribution made to the understanding of the epidemiology of osteoarthritis by the Arthritis Research Campaign Epidemiology Unit. Kellgren and Lawrence defined the condition radiographically and produced the widely used Atlas of Standard Radiographs of Arthritis. They documented the age- and sex-specific prevalence of osteoarthritis. Based on studies in occupational gro...

Kondal, Sudeep Kulkarni, Viraj Gaikwad, Ashrika Kharat, Amit Pant, AniruddhaThe severity of knee osteoarthritis is graded using the 5-point Kellgren-Lawrence scale where healthy knees are assigned grade 0, and subsequent grades 1–4 represent increasing affliction. Although several methods have been proposed in recent years to develop models that can automatically predict from a given radiograph...