The prognosis of progressive ophthalmoplegia in patients with large-scale mitochondrial DNA deletions is highly variable and almost unpredictable. The risk to develop cardiac involvement and sudden cardiac death is strikingly high, especially in patients with Kearns-Sayre syndrome (KSS). The most typical cardiac complications of the disease are conduction defects, which usually begin with left ...

We study the Price of Anarchy (PoA) of the competitive cascade game following the framework proposed by Goyal and Kearns in [11]. Our main insight is that a reduction to a Linear Threshold Model in a time-expanded graph establishes the submodularity of the social utility function. From this observation, we deduce that the game is a valid utility game, which in turn implies an upper bound of 2 o...

We study the properties of the agnostic learning framework of Haussler [Hau92] and Kearns, Schapire and Sellie [KSS94]. In particular, we address the question: is there any situation in which membership queries are useful in agnostic learning? Our results show that the answer is negative for distribution-independent agnostic learning and positive for agnostic learning with respect to a specific...

Examination of the retinal tissues obtained at necropsy from a 14-year-old boy with Kearns-Sayre syndrome showed marked photoreceptor and pigment epithelial cell loss in the retinal periphery and around the optic nerve head. Electron microscopy of surviving retinal pigment epithelial (RPE) cells indicated a loss of apical microvilli and basal infoldings. The RPE was unusually devoid of melanoso...

To cite: Sharma AK, Jain N, Kharwar RB, et al. BMJ Case Rep Published online: [please include Day Month Year] doi:10.1136/bcr-2016216500 DESCRIPTION We describe the images of a 27-year-old man presenting with recurrent syncope due to complete heart block (figure 1). The patient, on further examination, showed ophthalmoplegia, bilateral ptosis (figure 2) and pigmentary retinopathy (figure 3). Ke...

We study the properties of the agnostic learning framework of Haussler (1992) and Kearns, Schapire, and Sellie (1994). In particular, we address the question: is there any situation in which membership queries are useful in agnostic learning? Our results show that the answer is negative for distribution-independent agnostic learning and positive for agnostic learning with respect to a specific ...