To the Editor: Dupilumab has demonstrated good efficacy and tolerable safety in adult patients with moderate to severe atopic dermatitis long term clinical trials,1Deleuran M. Thaci D. Beck L.A. et al.Dupilumab shows long-term enrolled a phase 3 open-label extension study.J Am Acad Dermatol. 2020; 82: 377-388Abstract Full Text PDF PubMed Scopus (89) Google Scholar but real-world data are limite...

the phenomena of extensive air shower (eas) are produced by the collision of primary cosmic rays (cr) with energy more than ev with the atmospheric molecules. as a result the electron and muon components (cascades) of eas develop through the air.  the study of such cascades gives important information about the primary cr mass composition as well as its astrophysical origin models. one of the e...

Low levels of phosphorus and high levels of aluminum are important soil acidity factors for the growth of higher plants; however, very little is known about their effects on the soil rhizobia. The present study was conducted to determine the relative effects of acidity, P, and Al on rhizobia. Tolerance of low pH (4.5), low P (510 μM), and high AI (50 μM) was assessed for 10 strains of cowpea rh...

GLUCOKINASE (GK) is the enzyme that converts glucose, a major fuel of the body, into glucose-6-phosphate (G-6-P) in liver, pancreatic beta cells, and some specialized neurons, as well as enteroendocrine and pituitary cells (12). G-6-P is the gateway to the major pathways of glucose utilization: glycolysis, the oxidation of glucose, the pentose phosphate pathway, and glycogenesis. GK performs di...

An X-ray crystal structure of lithium 2,3,3-trimethylindolenide therate shows it to be a disolvated dimer having a 7)-azaallyl-type structure. The structures of the salt in several solvents have been established by studies of I3C chemical shifts, 6Li,15N spinspin splitting, 7Li quadrupole splitting constants, and apparent degrees of aggregation determined by vapor pressure barometry. It is the ...

Global warming has become a major concern around the world. The Paris Agreement of 2015 (UNFCCC, 2015) mandates reduction CO2 emissions in developed countries, and subsequently renewable energy sources that produce significantly fewer greenhouse gases, such as wind, solar geothermal, have increased rapidly since 2000s. relatively low cost construction maintenance wind power generators makes it ...

Epithelial-mesenchymal transition (EMT) is a crucial event in cancer progression. We previously reported that EMT up-regulates matrix metalloproteinase-2 (MMP-2) expression in squamous cell carcinoma (SCC) cells. In this study, we showed that Tet Off-induced expression of Snail or SIP1, and treatment with TGF-ß1 induced EMT in terms of down-regulation of E-cadherin, and up-regulation of vimenti...

Clinically used GPIIb/IIIa blockers are ligand mimetics, and thereby their binding can induce conformational changes of the platelet integrin GPIIb/IIIa. Since the reversibility of these conformational changes may be an important determinant of potential adverse effects of GPIIb/IIIa blockers, we produced a new monoclonal antibody (anti-LIBS-mAb), and by using its binding properties, we investi...

Methyldihydrodithiepins are converted into the corresponding carboxaldehydes via a simple and efficient oxidation by oxygen in carbon tetrachloride. The reaction is not a radical chain process. The proposed mechanism involves photoinduced electron transfer from the starting dithiepin to solvent (CCl4) followed by a series of events depicted in Scheme 1. The critical feature of the mechanism is ...

We describe a technique for the quick and simple assessment of doped optical materials for use as laser gain media. To demonstrate this technique, referred to as Rapid Thermo-Optical Assessment (RTOA), we analyze a set of ceramic and crystalline Yb:YAG samples. RTOA is based on Shack-Hartmann wavefront sensing and thermal lensing to evaluate the media’s thermal response, giving a relative overa...