نتایج جستجو برای: k562 cell line
تعداد نتایج: 1970287 فیلتر نتایج به سال:
Background : Cancer is a complex disease with genetic alterations. One of the many ways to improve and prevent this patient is chemotherapy that due to the emergence of drug resistance, side effects of synthetic drugs and high medical potential of plants, the aim of this study was to investigate anticancer activity of the methanolic extract of Allium Jesdianum and Nectaroscordeum Coelzi (Liliac...
the cytotoxic activity of ethanolic extracts of thymus vulgaris, thuja orientalis and achillea millefolium was investigated on various growing tumor cell lines. mtt colorimetric assay was used for measuring the inhibition of cell proliferation. all of the three extracts showed a relatively dose-dependent inhibition of proliferation of human breast cancer (sk-br-3, mda-mb-435) and leukemia (u937...
A daunorubicin-resistant variant of the K562 human leukemia cell line (K562-R), which demonstrates cross-resistance to other anthracycline antibiotics and Vinca alkaloids, has been developed in vitro by continuous exposure to daunorubicin. Cross-resistance to anthracyclines and Vinca alkaloids is reversed when cells are exposed to drugs in the presence of verapamil, a calcium channel blocker. T...
The ability of cells derived from the K562 cell line to generate erythropoietic colonies was studied. The K562 cell line was derived from a patient with chronic myelogenous leukemia 8 yr ago by Lozzio and Lozzio. Rare benzidine-positive colonies formed when these cells were cloned in plasma clots (3 +/- 1/10(4) cells), and their number was not substantially increased by the addition of erythrop...
We report that erythroid-potentiating activity (EPA). known to stimulate the proliferation of normal human erythroid precursors in vitro. has a growth-promoting effect on human K562 erythroleukemia cells and Friend mouse erythroleukemia cells. Detailed studies were carried out using an EPA produced by a human T-lymphoblast line (Mo). Although EPA has not been purified to homogeneity. several ob...
Erythroid differentiation is mediated by several interacting factors which include the glycoprotein hormone erythropoietin (Epo), interleukin-3 (IL-3) in the mouse, and erythroid-potentiating activity (EPA) in humans. Each of these factors binds to specific cell surface receptors on responsive target cells, but the way in which these factors interact to modulate erythropoiesis is unknown. In th...
Aim and Background: Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder with cytogenetic characterization of the abnormal Philadelphia chromosome. This chromosome results from a reciprocal translocation between chromosomes 9 and 22. This is an important signaling pathway in the process of cancer cell proliferation and apoptosis, as well as the pathogenesis of TGF-β disease, i...
Background and purpose: Royal jelly (RJ) is a substance synthesized by worker bee- is shown to have various biological activities on different cells and tissues of the human body. In this study the effect of RJ on peripheral blood mononuclear cells cytotoxicity against the K562 Erythroleukemia cell line was investigated. Material and methods: In this experimental study human PBMCs (106 cell...
The human leukemia cell line K562 was derived from a patient with chronic granulocytic leukemia. This cell line has subsequently been shown to possess phenotypic markers typical of erythroid and myeloid cells. Using a rabbit antiserum directed against purified platelet glycoproteins (PGPs), we have obtained evidence for the constitutive expression of PGPs on the surface of K562 cells. PGPs expr...
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