Mice lacking a functional Ren-1(d) gene exhibit a complete lack of renal juxtaglomerular cell granulation and atypical macula densa morphology. Transgenic mice carrying a 145-kilobase BAC clone encompassing the Ren-1(d) and Ren-2 loci were generated, characterized, and backcrossed with Ren-1(d-/-) mice. Homozygous Ren-1(d)-null mice expressing the BAC clone exhibited complete restoration of nor...

malignant germ-cell tumors (mgct) are rare tumors of childhood accounting for less than 3% of pediatric malignancies. endodermal sinus tumor (est) forms the most common histologic subtype of mgct. the vagina is an extremely rare site for gcts. an 8-month-old female was admitted with a short history of vaginal bleeding, and a mass protruding from the vagina. she was pale and a mass was palpable ...

giant cell tumors (gct) are benign tumors with potential for aggressive behavior and capacity to metastasize. although rarely lethal, benign bone tumors may be associated with a substantial disturbance of the local bony architecture that can be particularly troublesome in peri-articular locations. its histogenesis remains unclear. it is characterized by a proliferation of mononuclear stromal ce...

• Increasing evidence has accumulated to support the juxtaglomerular cell rather than the proximal tubular cell as being the site of renin formation in the kidney. The determination of the site of renin is important to the elucidation of the mechanism of stimulation of the renin-angiotensin pressor system. Goormaghtigh^ first demonstrated changes in the juxtaglomerular cell which indicated a se...

• Increasing evidence has accumulated to support the juxtaglomerular cell rather than the proximal tubular cell as being the site of renin formation in the kidney. The determination of the site of renin is important to the elucidation of the mechanism of stimulation of the renin-angiotensin pressor system. Goormaghtigh^ first demonstrated changes in the juxtaglomerular cell which indicated a se...

We have shown previously that decreasing intracellular calcium in the juxtaglomerular cells increases both cAMP formation and renin release. We hypothesized that this is because of an interaction between intracellular calcium and the calcium-inhibitable isoform of adenylyl cyclase, type-V. We used primary cultures of juxtaglomerular cells isolated from C-57/B6 mice at 70% to 80% confluence. Wes...

In many brain regions, hyperpolarization-activated cationic currents (Ih) are involved in the generation of rhythmic activities, but the role of Ih in olfactory oscillations remains unclear. Knowledge of the cellular and subcellular distributions of hyperpolarization-activated and cyclic nucleotide-gated channel (HCN) subunits is necessary for understanding the role of Ih in olfactory network a...

objective: dendritic cells (dcs) are essential for the activation and polarization of t cells during an adaptive immune response. in this research we investigated the effect of the lymphoide dcs pulsed with heat-treated tumor lysate (htl) as a vaccine in tumor immunotherapy. materials and methods: the balb/c mice were injected subcutaneously in the right flank with wehi-164 fibrosarcoma cells ...