SCHMIDT-NIELSEN, BODIL, AND ROBERTA O’DELL. Structure and concentrating mechanism in the mammalian kidney. Am. J. Physiol. 200 (6) : I I I g-I I 24. 1961 .-In a number of mammalian kidneys a close correlation was found between renal medullary thickness and ability to concentrate electrolytes in the urine, indicating that both outer and inner zone of the medulla act as a countercurrent multiplie...

A case is presented of apparent epilepsy which proved to be due to recurrent ventricular tachyarrhythmias (torsade de pointe). The relationship between the cardiac arrhythmia and changes in the electroencephalograph is recorded and analysed. This is probably an example of the 'Jervell Lange-Neilson' syndrome of cardiac arrhythmias which may produce ictal episodes, prolongation of the QTc interv...

We consider strictly stationary infinitely divisible processes and first extend the mixing conditions given in Maruyama [18] and Rosiński and Żak [23] from the univariate to the d-dimensional case. Thereafter, we show that multivariate Lévy-driven mixed moving average processes satisfy these conditions and hence a wide range of well-known processes such as superpositions of Ornstein-Uhlenbeck (...

A note on exact likelihoods of the Carr-Wu models for leverage effects and volatility in financial economics. show that most stochastic processes used in traditional option pricing models can be cast as special cases of time-changed Lévy processes. In particular these are models which can be tailored to exhibit correlated jumps in both the log price of assets and the instantaneous volatility. N...

With the increasing control of congenital syphilis, paroxysmal cold haemoglobinuria has become a very rare disorder in childhood. Cases which occur now are more likely to be associated with acute infectious diseases (Kissmeyer-Nielsen and Schleisner, 1963). However, despite the frequency of measles in children, paroxysmal cold haemoglobinuria (PCH) has only previously been described as a compli...

Inherited long QT syndrome is most frequently associated with mutations in KCNQ1, which encodes the primary subunit of a potassium channel. Patients with mutations in KCNQ1 may show only the cardiac defect (Romano-Ward syndrome or RWS) or may also have severe deafness (Jervell and Lange-Nielsen syndrome or JLNS). Targeted disruption of mouse Kcnq1 models JLNS in that mice are deaf and show abno...

This essay looks at the historical significance of five APS classic papers that are freely available online: Murdaugh HV Jr, Schmidt-Nielsen B, Doyle EM, and O’Dell R. Renal tubular regulation of urea excretion in man. J Appl Physiol 13: 263–268, 1958. (http://jap.physiology.org/cgi/reprint/13/2/263) Schmidt-Nielsen B. Renal tubular excretion of urea in kangaroo rats. Am J Physiol 170: 45–56, 1...

Jackson DC. Academic genealogy and direct calorimetry: a personal account. Adv Physiol Educ 35: 120 –127, 2011; doi:10.1152/advan.00121.2010.—Each of us as a scientist has an academic legacy that consists of our mentors and their mentors continuing back for many generations. Here, I describe two genealogies of my own: one through my PhD advisor, H. T. (Ted) Hammel, and the other through my post...