This label is applied to a group of patients whose neurological and psychiatric symptoms are somewhat varied and whose brains show pathological changes which are basically similar, although their distribution and extent in the nervous system may vary (Siedler and Malamud, 1963). In the early 19203 A. Jakob (1921, 1923) described five patients aged between 30 and 50 who had presented with somewh...

BACKGROUND The objective of this study was to describe the diagnostic panorama of human transmissible spongiform encephalopathies across 11 countries. METHODS From data collected for surveillance purposes, we describe annual proportions of deaths due to different human transmissible spongiform encephalopathies in eleven EUROCJD-consortium countries over the period 1993-2002, as well as variat...

Creutzfeldt-Jakob disease is a 'slow virus' illness usually presenting as a rapidly progressive dementia. Although rare, its laboratory and accidental transmission has given it great theoretical importance. However, the infective agent remains mysterious and it is not known how, or even whether, natural transmission occurs. Clinical diagnosis is difficult, treatment unfortunately unsuccessful a...

43. Jayanthi P, Thomas P, Bindhu P, Krishnapillai R. Prion diseases in humans: oral and dental implications. N Am J Med Sci. 2013;5:399–403. http://dx.doi.org/10.4103/1947-2714.115766 44. Peden A, McCardle L, Head MW, Love S, Ward HJ, Cousens SN, et al. Variant CJD infection in the spleen of a neurologically asymptomatic UK adult patient with haemophilia. Haemophilia. 2010; 16:296–304. http://d...

OBJECTIVE To determine the strength of association between history of blood transfusion and development of Creutzfeldt-Jakob disease. DATA SOURCES English and non-English language articles published from January 1966 to January 1999 were retrieved using a keyword search of Medline and Embase. These were supplemented by handsearching key journals and searching bibliographies of reviews. STUD...

OBJECTIVES During an epidemiological study of Creutzfeldt-Jakob disease in Germany, Hashimoto's encephalitis was encountered as a differential diagnosis, which has not yet been described in this context. METHODS The symptoms and findings of seven patients who fulfilled the criteria for "possible" Creutzfeldt-Jakob disease are presented. RESULTS A Hashimoto's thyroiditis with antibodies agai...