The cytochrome P450 sterol 14alpha-demethylase enzyme (CYP51) is the target of azole antifungals. Azoles block ergosterol synthesis, and thereby fungal growth, by binding in the active-site cavity of the enzyme and ligating the iron atom of the heme cofactor through a nitrogen atom of the azole. Mutations in and around the CYP51 active site have resulted in azole resistance. In this work, homol...

Complex environmental factors can significantly influence the micro-properties of porous asphalt (PA) mixture. Therefore, effects short-term and long-term thermal aging moisture immersion on micromechanics properties, micro-morphology, chemical element distributions interfacial transition zone (ITZ) PA mixture were studied to reveal mechanisms by which degradation impact performance means nanoi...

The flexural strength of ultra-high performance concrete with basalt aggregates (UHPC-CA) strongly depends on the micromechanical property CA, interfacial transition zone (ITZ) and matrix. However, influence rate-dependent UHPC-CA has not been well understood. Here, different initial distributions are produced by controlling hydration development, its influences investigated a multi-scale analy...

The concrete–rock interfacial transition zone (ITZ) is generally considered the weak layer in hydraulic engineering, for it more permeable than intact concrete or rocks. water permeability of ITZ a critical parameter concerned with structural safety and durability. However, pore structure has not been investigated previously, mathematical model established. This study performed multi-scale expe...

results the sequence analysis of the isolate confirmed as c. glabrata and deposited on ncbi genbank under the accession number no. kt763084-kt763123. the geometric mean mics against all the tested strains were as follows, in increasing order: casp (0.17 g/ml), vcz (0.67 g/ml), amb (1.1 g/ml), itz (1.82 g/ml), ktz (1.85 g/ml), and fcz (6.7 g/ml). the resistance rates of the isolates to casp, fcz...

An increasing amount of construction and demolishing waste has made the implementation recycled concrete aggregate (RCA) a popular topic; RCA can reduce environmental pollution caused by industry. This paper describes differences in physical, mechanical, chemical properties between natural (NA). For first time, methods interfacial transition zone (ITZ) improvement RCA, including strengthening t...

This article has not been copyedited and formatted. The final version may differ from this version. Abstract The purpose of this study was to determine the impact of CYP3A5 expression on inhibitory potency (K i or IC 50 values) of CYP3A inhibitors, using recombinant CYP3A4 and CYP3A5 (rCYP3A4 and rCYP3A5) and CYP3A5 genotyped human liver microsomes (HLMs). IC 50 ratios between rCYP3A4-and rCYP3...

The purpose of this study was to determine the impact of CYP3A5 expression on inhibitory potency (Ki or IC50 values) of CYP3A inhibitors, using recombinant CYP3A4 and CYP3A5 (rCYP3A4 and rCYP3A5) and CYP3A5 genotyped human liver microsomes (HLMs). IC50 ratios between rCYP3A4 and rCYP3A5 (rCYP3A5/rCYP3A4) of ketoconazole (KTZ) and itraconazole (ITZ) were 8.5 and 8.8 for midazolam (MDZ), 4.7 and ...