Background & objective: Pruritus is the most frequent chronic dermal complication of sulfur mustard (SM), which negatively influences the quality of life. Exact pathophysiology of SM-induced itching is unknown. The current study aimed at evaluating the possible association between SM-induced itching and the serum levels of matrix metalloproteinase (MMP...

The objective of the study was to evaluate itchingoccasionally observed in cats and dogs shortly afteradministration of nitenpyram(Capstar; NovartisAG, Basel, Switzerland).Twelve cats and twelve dogs were caged individual-ly, infested with 100 fleas, and dosed with niten-pyram 24 hours later. Cats and dogs were dosed withtablets containing 11.4 mg and 57.0 mg nit...

BACKGROUND While intractable itching may be rarely associated with postherpetic neuralgia, it can have catastrophic complications if present. METHOD We highlight a severe case of postherpetic itching in a 10-year-old male with Fanconi's and aplastic anemia, refractory to conventional treatments and requiring intravenous sedation. RESULTS Our use of 3 sequential stellate ganglion blocks with...

Cowhage, capsaicin and histamine, all applied via spicules, were used to induce itch and pain-related sensations in 15 male and 15 female subjects. Sensory qualities were assessed by questionnaire; intensities and time courses of the "itching" and "burning" sensation were measured alternately, but continuously on a VAS. In addition, axon reflexes were assessed. Only histamine and capsaicin prod...

OBJECTIVES The aim was to develop a clinical outcome assessment (COA) for itching in children with cholestatic pruritus. METHODS This prospective study aimed to enroll patients aged 4-30 years with Alagille syndrome (ALGS) or progressive familial intrahepatic cholestasis type 1 and caregivers of patients aged 5 months to 14 years. Eligible patients experienced itching during ≥3 of the 7 days ...

Postoperative itching is an important problem in the postoperative care unit. Pruritus after surgery may be drug induced (including intrathecal opioids) or secondary to a preexisting systemic disease. Mechanisms of itching are complex and not completely understood. The purpose of this review is to highlight new discoveries in pathways and mechanisms of pruritus and to summarize up-to-date knowl...