The application of stable isotope analysis (SIA) has become a standard scientific approach in Agricultural and Ecological researches and, more in general, in several disciplines such as biology, botany, zoology, organic chemistry, climatology, and nutrition. The main objectives of this paper are (1) to provide a simple definition of stable isotopes and (2) to illustrate analytical measurement m...

Introduction Selenium is an essential element to human health at low levels (2080 μg/L), but becomes toxic at elevated levels. Selenium exists in different forms that determine its toxicity and bioavailability. Current research is now focusing on the determination of individual selenium species or seleniumcontaining compounds. This can be done using ICP-MS as a selenium-specific detector for a ...

Understanding the transport and behavior of bacteria in the environment has broad implications in diverse areas, ranging from agriculture to groundwater quality, risk assessment, and bioremediation. The ability to reliably track and enumerate specific bacterial populations in the context of native communities and environments is key to developing this understanding. We report a novel bacterial ...

The practice of immunoassay has experienced a widespread transition from radioisotopic labeling to nonisotopic labeling over the last two decades. Radioisotope labels have drawbacks that hamper their applications: (i) perceived radiation hazards of reagents, (ii) regulatory requirements and disposal problems of working with radioactive materials, and (iii) short shelf-life of the labeled reagen...

1,4-Dioxane: The Impact of Analytical Method -A Case Study Linton, P.J., J.C. Alonso, and T. Armstrong. Proceedings of the Sixth International Conference on Remediation of Chlorinated and Recalcitrant Compounds (Monterey, CA; May 2008). Battelle Press, Columbus, OH, ISBN 1­ 57477-163-9, Abstract G-005, 2008 Commercial laboratories commonly analyze for 1,4-dioxane in groundwater by either EPA Me...

Stable isotope assisted metabolomics techniques have emerged as a valuable tool in systems biology for metabolic flux analysis and pathway discovery (Duckwall et al., 2013; Chokkathukalam et al., 2014; Niedenführ et al., 2015). Traditionally, stable isotope labeling analyses have been highly targeted, meaning that isotopic enrichment of only a small set of metabolites has been analyzed to deduc...

A twoplex method using (12)C6 and (13)C6 stable isotope analogues (Δmass = 6 Da) of 2-aminobenzoic acid (2-AA) is described for quantitative analysis of N-glycans present on monoclonal antibodies and other glycoproteins using ultra performance liquid chromatography with sequential fluorescence and accurate mass tandem quadrupole time of flight (QToF) mass spectrometric detection.